A register-based study of the association between air pollutants and hypertensive disorders in pregnancy among the Japanese population
A register-based study of the association between air pollutants and hypertensive disorders in pregnancy among the Japanese population
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DOI：
10.1016/j.envres.2015.08.024
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发表时间：
2015-10-01
影响因子：
8.3
通讯作者：
Nitta, Hiroshi
中科院分区：
文献类型：
--
作者：
Michikawa, Takehiro;Morokuma, Seiichi;Nitta, Hiroshi
背景资料：环境空气污染被认为是妊娠期高血压疾病的一个危险因素，这是一种主要的妊娠并发症。过去的研究报告了支持的证据，但这主要是指西方人口，从三个月的具体分析的结果已经有所不同。方法：以日本围产期登记网络数据库为基础，对2005年至2010年在日本西部（九州和冲绳地区）的36,620名无医疗并发症的单胎孕妇进行研究。此外，还获得了臭氧、悬浮颗粒物（SPM）、二氧化氮（NO2）和二氧化硫（SO2）浓度的数据。最近的监测站，以各自的分娩医院作为参考点，分配每一个妇女在怀孕的头三个月的每一种污染物的平均浓度。Logistic回归模型被应用于评估之间的关联五分之一的每种污染物和高血压disorders in pregnancy.Results：平均浓度在妊娠早期分别为41.3 ppb的臭氧，27.4 μ g/m（3）的SPM，11.8 ppb的NO2，和3.2 ppb的SO2。高臭氧暴露与妊娠期高血压疾病的风险增加有关（最高五分位数与最低五分位数：比值比= 1.20，95%置信区间=1.01-1.42）。关于SPM，NO2和SO2，我们没有得到结果与恒定的directional.Conclusions：臭氧暴露在妊娠早期可能是妊娠期高血压疾病的危险因素。(C)2015 Elsevier Inc. All rights reserved.
Background: Ambient air pollution is hypothesized to be a risk factor for hypertensive disorders in pregnancy, one of the major pregnancy complications. Past studies have reported the supporting evidence, however this mainly referred to the Western population, and results from trimester-specific analysis have been varied. In this study, we focused on exposure during the first trimester of pregnancy (placental development stage), and tested the hypothesis among the Japanese population.Methods: We drew on data from the Japan Perinatal Registry Network database, and studied 36,620 singleton pregnant women without medical complications, in western Japan (Kyushu and Okinawa districts) between 2005 and 2010. In addition, data on ozone, suspended particulate matter (SPM), nitrogen dioxide (NO2), and sulfur dioxide (SO2) concentrations were obtained. The nearest monitoring station to the respective birthing hospital was used as a reference point for assigning average concentrations of each pollutant during the first trimester of pregnancy for each woman. The logistic regression model was applied to assess the association between quintiles of each pollutant and hypertensive disorders in pregnancy.Results: Mean concentrations during the first trimester were 41.3 ppb for ozone, 27.4 mu g/m(3) for SPM, 11.8 ppb for NO2, and 3.2 ppb for SO2. High exposure to ozone was associated with an increased risk of hypertensive disorders in pregnancy (for highest quintile vs. lowest: odds ratio= 1.20, 95% confidence interval=1.01-1.42). With regard to SPM, NO2 and SO2, we did not obtain the results with constant directionality.Conclusions: Ozone exposure during early pregnancy may be a risk factor for hypertensive disorders in pregnancy. (C) 2015 Elsevier Inc. All rights reserved.