Two types of social buffering differentially mitigate conditioned fear responses
Two types of social buffering differentially mitigate conditioned fear responses
复制标题
DOI：
10.1111/j.1460-9568.2007.05969.x
复制
发表时间：
2007-12-01
影响因子：
3.4
通讯作者：
Mori, Yuji
中科院分区：
文献类型：
--
作者：
Kiyokawa, Yasushi;Takeuchi, Yukari;Mori, Yuji
在各种物种中，有一种被称为“社会缓冲”的现象，来自同种动物的信号可以减轻压力反应。这种缓冲可以通过在应激事件后的“成对住房”或通过与同种动物“成对暴露”于急性应激源来实现。在这项研究中，我们比较了这两种类型的社会缓冲对听觉条件性恐惧反应的影响。当受试者暴露于听觉条件刺激（CS），已配对的前一天的脚电击，他们清楚地表现出行为（冻结），自主神经（加重压力引起的高热）和神经（Fos表达）的反应。对住房24小时后，一个陌生的大鼠恐惧条件导致抑制自主神经，但不行为，反应，与Fos表达在杏仁核和腹外侧导水管周围灰质的外侧核。另一方面，对暴露于CS与一个不熟悉的大鼠消除了行为，但不是自主神经，反应，与Fos的表达在基底核的杏仁核和边缘下区的前额叶皮层。此外，已经成对安置然后成对暴露的受试者没有表现出行为，自主或神经反应，这表明这两个程序的组合可以完全阻断恐惧条件反射序列。这些结果表明，两种类型的社会缓冲差异缓解条件性恐惧反应，通过影响不同的神经通路在杏仁核。
In a phenomenon known as 'social buffering' in various species, signals from a conspecific animal can mitigate stress responses. This buffering can be achieved either by 'pair-housing' after a stressful event or by 'pair-exposure' to an acute stressor with a conspecific animal. In this study, we compared the impacts of these two types of social buffering on auditory conditioned fear responses in male rats. When subjects were exposed to an auditory conditioned stimulus (CS) that had been paired with foot shocks on the previous day, they clearly exhibited behavioral (freezing), autonomic (aggravated stress-induced hyperthermia) and neural (Fos expression) responses. Pair-housing for 24 h with an unfamiliar rat following fear conditioning resulted in a suppressed autonomic, but not behavioral, response, with Fos expression in the lateral nucleus of the amygdala and ventrolateral periaqueductal gray. On the other hand, pair-exposure to the CS with an unfamiliar rat eliminated the behavioral, but not the autonomic, response, with Fos expression in the basal nucleus of the amygdala and infralimbic region of the prefrontal cortex. Furthermore, subjects that had been pair-housed and then pair-exposed showed no behavioral, autonomic or neural responses, suggesting that the combination of the two procedures can completely block the fear conditioning sequence. These results demonstrate that two types of social buffering differentially relieve conditioned fear responses, by influencing different neural pathways in the amygdala.