Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma
复制标题
使用恢复期血浆治疗 5 名 COVID-19 危重患者。
DOI：
10.1001/jama.2020.4783
复制
发表时间：
2020-04-28
影响因子：
120.7
通讯作者：
Liu, Lei
中科院分区：
文献类型：
--
作者：
Shen, Chenguang;Wang, Zhaoqin;Liu, Lei
问题 恢复期血浆输注对于治疗 2019 年冠状病毒病 (COVID-19) 危重患者是否有益？结果 在这个由 5 名患有 COVID-19 和急性呼吸窘迫综合征 (ARDS) 的危重患者组成的不受控制的病例系列中，给予含有中和抗体的恢复期血浆后，临床状况得到改善。意义 这些初步研究结果提出了恢复期血浆输注可能有助于治疗 COVID-19 和 ARDS 危重患者的可能性，但这种方法需要在随机临床试验中进行评估。 重要性 2019 年冠状病毒病 (COVID-19) 是一种流行病，没有特效治疗药物，死亡率很高。寻找新的治疗方法至关重要。目的 确定恢复期血浆输注是否有益于治疗严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染的危重患者。设计、背景和参与者 病例系列由 5 名实验室确诊的 COVID-19 和急性呼吸窘迫综合征 (ARDS) 危重患者组成，这些患者符合以下标准：尽管接受抗病毒治疗，但严重肺炎进展迅速且病毒载量持续较高； Pao(2)/Fio(2)
Question Could administration of convalescent plasma transfusion be beneficial in the treatment of critically ill patients with coronavirus disease 2019 (COVID-19)? Findings In this uncontrolled case series of 5 critically ill patients with COVID-19 and acute respiratory distress syndrome (ARDS), administration of convalescent plasma containing neutralizing antibody was followed by an improvement in clinical status. Meaning These preliminary findings raise the possibility that convalescent plasma transfusion may be helpful in the treatment of critically ill patients with COVID-19 and ARDS, but this approach requires evaluation in randomized clinical trials.Importance Coronavirus disease 2019 (COVID-19) is a pandemic with no specific therapeutic agents and substantial mortality. It is critical to find new treatments. Objective To determine whether convalescent plasma transfusion may be beneficial in the treatment of critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Design, Setting, and Participants Case series of 5 critically ill patients with laboratory-confirmed COVID-19 and acute respiratory distress syndrome (ARDS) who met the following criteria: severe pneumonia with rapid progression and continuously high viral load despite antiviral treatment; Pao(2)/Fio(2)