Maternal risk factors for low birth weight for term births in a developed region in China: a hospital-based study of 55,633 pregnancies.
Maternal risk factors for low birth weight for term births in a developed region in China: a hospital-based study of 55,633 pregnancies.
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中国发达地区足月出生体重低的孕产妇危险因素：基于医院的 55,633 例妊娠研究
DOI：
10.7555/jbr.27.20120046
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发表时间：
2013-01
影响因子：
2.3
通讯作者：
Wang S
中科院分区：
文献类型：
--
作者：
Bian Y;Zhang Z;Liu Q;Wu D;Wang S
低出生体重是新生儿和婴儿死亡率和成人发病率的一个重要危险因素。然而，在中国还没有大规模的研究，对低出生体重的患病率和相关的孕产妇危险因素，已公布。为探讨母体因素对中国足月分娩低出生体重的影响，我们对2001年至2008年期间55633例中国妊娠病例进行了一项以医院为基础的回顾性研究。获得产妇的社会人口学数据、不孕症史和避孕药使用情况。在第一次产前检查时，通过体格检查检查她们的健康状况和孕前疾病。记录产妇分娩前的医疗状况和妊娠结局，包括体重、婴儿性别、多胎妊娠和先天性畸形。采用单因素、多因素Logistic回归和线性回归分析母亲因素与足月低出生体重的关系。在我国经济发达地区，足月低出生体重的总发生率为1.70%。经单因素模型初步分析后，在多因素模型中，小学文化程度低、贫血、高血压、前置胎盘、羊水过少和胎膜早破是足月低出生体重的独立预测因素。此外，这些危险因素年发生率的下降是低出生体重发生率逐渐下降（从2001年的2.43%下降到2008年的1.21%）的主要原因。研究表明，即使在中国最发达的地区，母亲的文化程度、贫血和高血压疾病也可能是足月出生低出生体重的原因。
Low birth weight (LBW) is an important risk factor for neonatal and infant mortality and morbidity in adults.. However, no large scale study on the prevalence of LBW and related maternal risk factors in China has been published. To explore the effects of maternal factors on LBW for term birth in China, we conducted a hospital-based retrospective study of 55, 633 Chinese pregnancy cases between 2001 and 2008. Maternal sociodemographic data, history of infertility and contraceptive use were obtained. Their medical status and diseases during pre-pregnancy were examined by physical examination at the first antenatal care visit. Maternal medical status before childbirth and pregnancy outcomes, including body weight, infant gender, multiple pregnancy and congenital anomalies, were recorded. Univariate and multivariate logistic regression, and linear regression were used to investigate the relationship between maternal factors and term LBW. The general incidence of term LBW was 1.70% in the developed area of China. After preliminary analysis using the univariate model, low primary education, anemia, hypertensive disorders, placental previa, oligohydramnios and premature rupture of membrane were predicted as independent factors of term LBW in the multivariate model. Furthermore, the decrease in annual frquencies of these risk factors were major causes of gradual decline in the incidence of LBW (from 2.43% in 2001 to 1.21% in 2008). The study demonstrated that among maternal factors, primary education, anemia and hypertensive disorders could contribute to LBW for term birth even in the most developed area of China.