Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children.
Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children.
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幽门螺杆菌在儿童中引起的胃炎症比成人少。在这里，我们研究了这种炎症的减少是否涉及Th 17反应失调。H.智利圣地亚哥的儿童和成人感染幽门螺杆菌的水平相似。pylori定植、含有cagA和s1/s2 vacA毒力标记物的细菌比例和菌株基因型（主要是hpEurope），但儿童的胃部炎症和中性粒细胞浸润水平显著降低。与感染成人相比，感染儿童中性粒细胞蓄积减少伴随着胃Th 17细胞显著减少和IL-17特异性mRNA和蛋白水平显著降低。H.幽门螺杆菌感染的儿童也含有较高数量的IL-10+细胞和IL-10和Foxp 3 mRNA水平的增加相比，感染的成人。因此，在H.幽门螺杆菌感染的儿童与感染的成人相比，可能是由于下调的胃Th 17/IL-17反应，作为增强的粘膜调节性T细胞活性的结果，在儿童。
Helicobacter pylori induces less gastric inflammation in children than adults. Here we investigated whether this reduced inflammation involves dysregulated Th17 responses. H. pylori-infected children and adults in Santiago, Chile had similar levels of H. pylori colonization, proportions of bacteria containing cagA and s1/s2 vacA markers of virulence and strain genotypes (predominantly hpEurope), but the children had significantly reduced levels of gastric inflammation and neutrophil infiltration. The reduced neutrophil accumulation in infected children was accompanied by significantly fewer gastric Th17 cells and significantly lower levels of IL-17-specific mRNA and protein compared to infected adults. The gastric mucosa of H. pylori-infected children also contained higher numbers of IL-10+ cells and increased levels of both IL-10 and Foxp3 mRNA compared to that of infected adults. Thus, reduced gastric inflammation, including diminished neutrophil accumulation, in H. pylori-infected children compared with infected adults is likely due to down-regulated gastric Th17/IL-17 responses as a consequence of enhanced mucosal regulatory T cell activity in the children.
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影响因子：
24.5
作者：
de Sablet T;Piazuelo MB;Shaffer CL;Schneider BG;Asim M;Chaturvedi R;Bravo LE;Sicinschi LA;Delgado AG;Mera RM;Israel DA;Romero-Gallo J;Peek RM Jr;Cover TL;Correa P;Wilson KT
通讯作者：
Wilson KT
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
29.4
作者：
DeLyria ES;Redline RW;Blanchard TG
通讯作者：
Blanchard TG
不同地理区域幽门螺杆菌的重组和克隆分组
影响因子：
3.6
作者：
Achtman, M;Azuma, T;van Doorn, LJ
通讯作者：
van Doorn, LJ
影响因子：
29.4
作者：
Bimczok, Diane;Grams, Jayleen M.;Smith, Phillip D.
通讯作者：
Smith, Phillip D.