Attitudes towards clinical research amongst participants and nonparticipants
Attitudes towards clinical research amongst participants and nonparticipants
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DOI：
10.1046/j.1365-2796.2002.00949.x
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发表时间：
2002-02-01
影响因子：
11.1
通讯作者：
Riis, P
中科院分区：
文献类型：
--
作者：
Madsen, SM;Mirza, MR;Riis, P
目标。调查癌症试验参与者和非参与者对临床研究的态度，并将结果与非癌症试验参与者之前的研究结果进行比较。在临床试验期间，参与试验的受访者收到了三份问卷。拒绝随机化的患者中的受访者回答了单一问卷。设置。随机癌症临床试验的参与者和非参与者。受试者。癌症试验中的41名参与者和47名非参与者。医生进行医学研究的利他动机被高度评价。对临床研究的态度在所有组中都是积极的。未参与调查的受访者是最不积极的。百分之八到百分之九的人认为，在实施一般保健服务之前，有必要进行科学测试。与未参与的受试者相比，受试者对自我和他人的参与都更为积极。参与的个人动机和利他动机都得到了很高的评价。不参与的主要原因是对“未知”的恐惧和/或对随机化的不安。只有少数人感觉到拒绝参加审判带来的道德问题。在非癌症参与者中，受访者对所提供的信息比癌症参与者和非癌症参与者都更满意。癌症参与者的负面经历通常与在体检预约时看太多医生有关的挫折感。对临床研究的态度通常是积极的，即使在没有参加癌症研究的人中也是如此。参与的个人动机和利他动机都得到了很高的评价。对“未知”的恐惧和对随机化的怨恨是放弃参与的主要原因。看太多的医生预约检查似乎是癌症试验参与者负面体验的一个重要因素。
Objectives. To investigate attitudes to clinical research amongst cancer trial participants and nonparticipants, and to compare results with those from previous studies amongst participants in noncancer trials.Design. Trial participating respondents were given three questionnaires during the clinical trials. Respondents amongst patients declining randomization answered a single questionnaire.Setting. Participants and nonparticipants in randomized clinical cancer trials. Subjects. Forty-one participants and 47 nonparticipants in cancer trials.Results. Altruistic motives of physicians to conduct medical research were highly rated. Attitudes towards clinical research were positive in all groups. with nonparticipant respondents being the least positive. Eight to nine tenths found scientific testing necessary before general health service implementation. Trial participants were, as compared with nonparticipating respondents, more positive towards both participation of self and others. Both personal and altruistic motives for participation were highly rated. Primary reasons for nonparticipation were fear of 'the unknown' and/or unease with randomization. Only a minority felt a moral problem created by declining trial participation. Respondents amongst noncancer participants were more satisfied with the information given than both cancer participants and cancer nonparticipants. Negative experiences in cancer participants generally dealt with frustration related to seeing too many physicians at check-up appointments.Conclusion. Attitudes towards clinical research are generally positive even in cancer nonparticipants. Both personal and altruistic motives for participation were highly rated. A fear of 'the unknown' and resentments towards randomization were primary reasons to renounce participation. Seeing too many physicians at check-up appointments seems to be an important factor for negative experiences in cancer trial participants.