Severe anaemia is associated with a higher risk for preeclampsia and poor perinatal outcomes in Kassala hospital, eastern Sudan.
Severe anaemia is associated with a higher risk for preeclampsia and poor perinatal outcomes in Kassala hospital, eastern Sudan.
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DOI：
10.1186/1756-0500-4-311
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发表时间：
2011-08-26
影响因子：
1.8
通讯作者：
Adam I
中科院分区：
文献类型：
--
作者：
Ali AA;Rayis DA;Abdallah TM;Elbashir MI;Adam I
怀孕期间贫血是主要的健康问题。关于贫血及其严重程度与孕产妇和围产期结局之间的关联，存在相互矛盾的文献。这是一项在苏丹东部卡萨拉医院进行的回顾性病例对照研究。对2008年1月至2010年12月分娩的重度贫血（血红蛋白（Hb）< 7 g/dl，n = 303）孕妇的医疗档案进行了审查。分析了社会人口学和产科数据，并与类似数量的轻度/中度贫血（Hb = 7-10.9 g/dl，n = 303）和无贫血（Hb > 11 g/dl，n = 303）妇女进行了比较。分别对每个结局指标进行Logistic回归分析：先兆子痫、子痫、早产、低出生体重（LBW）和死产。在卡萨拉医院分娩的有9 578名产妇，其中4 012名（41.8%）患有贫血症，303名（3.2%）患有严重贫血症。仅重度贫血患者先兆子痫的校正风险增加（OR = 3.6，95%CI：1.4-9.1，P = 0.007）。与无贫血的女性相比，轻度/中度贫血女性的LBW风险高2.5倍（95% CI：1.1-5.7），重度贫血女性高8.0倍（95% CI：3.8-16.0）。早产的风险随着贫血的严重程度而显著增加（与无贫血的妇女相比，轻度/中度贫血妇女的OR = 3.2，重度贫血妇女的OR = 6.6）。校正后死产风险仅在重度贫血时增加（OR = 4.3，95% CI：1.9-9.1，P < 0.001）。怀孕期间贫血的严重程度越高，先兆子痫、早产、LBW和死胎的风险就越大。应采取预防措施，减少怀孕期间贫血的发生率。
Anaemia during pregnancy is major health problem. There is conflicting literature regarding the association between anaemia and its severity and maternal and perinatal outcomes. This is a retrospective case-control study conducted at Kassala hospital, eastern Sudan. Medical files of pregnant women with severe anaemia (haemoglobin (Hb) < 7 g/dl, n = 303) who delivered from January 2008 to December 2010 were reviewed. Socio-demographic and obstetric data were analysed and compared with a similar number of women with mild/moderate anaemia (Hb = 7-10.9 g/dl, n = 303) and with no anaemia (Hb > 11 g/dl, n = 303). Logistic regression analysis was performed separately for each of the outcome measures: preeclampsia, eclampsia, preterm birth, low birth weight (LBW) and stillbirth. There were 9578 deliveries at Kassala hospital, 4012 (41.8%) women had anaemia and 303 (3.2%) had severe anaemia. The corrected risk for preeclampsia increased only in severe anaemia (OR = 3.6, 95% CI: 1.4-9.1, P = 0.007). Compared with women with no anaemia, the risk of LBW was 2.5 times higher in women with mild/moderate anaemia (95% CI: 1.1-5.7), and 8.0 times higher in women with severe anaemia (95% CI: 3.8-16.0). The risk of preterm delivery increased significantly with the severity of anaemia (OR = 3.2 for women with mild/moderate anaemia and OR = 6.6 for women with severe anaemia, compared with women with no anaemia). The corrected risk for stillbirth increased only in severe anaemia (OR = 4.3, 95% CI: 1.9-9.1, P < 0.001). The greater the severity of the anaemia during pregnancy, the greater the risk of preeclampsia, preterm delivery, LBW and stillbirth. Preventive measures should be undertaken to decrease the prevalence of anaemia in pregnancy.