Methodology in conducting a systematic review of systematic reviews of healthcare interventions.

Methodology in conducting a systematic review of systematic reviews of healthcare interventions.
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DOI:
10.1186/1471-2288-11-15
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发表时间:
2011-02-03
影响因子:
4
通讯作者:
Clarke M
Clarke M
中科院分区:
医学3区
文献类型:
--
作者:
Smith V;Devane D;Begley CM;Clarke M

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已经发表了数百项关于产妇护理干预措施的研究,对于大多数参与提供产妇护理的人来说,太多了,无法在决策时确定和考虑。很明显,需要对单个研究进行系统评价,以评估,总结并将现有的研究集中在一个地方。然而,决策者越来越多地面临大量此类审查,而且这些审查的质量和范围可能各不相同,对重要主题的审查不止一次。综述的系统性综述(或综述)是合乎逻辑和适当的下一步,允许比较和对比单独综述的结果,为临床决策者提供他们需要的证据。描述了用于系统地识别和评价已发表和未发表综述的方法,借鉴了我们在系统综述的实施和报告方面的经验和良好实践。识别和评估所有已发表综述的过程允许研究人员描述该证据基础的质量,总结和比较综述的结论,并讨论这些结论的强度。方法学挑战和可能的解决方案在以下方面进行了描述:(i)来源,(ii)研究选择,(iii)质量评估(即为综述进行的检索范围,研究选择和纳入标准的描述,纳入研究的可比性,发表偏倚的评估和异质性的评估),(iv)结果的呈现,以及(v)对实践和研究的影响。对审查进行系统审查突出表明,如果对一个重要主题进行了不止一次审查,则将审查摘要集中在一处是有用的。这里描述的方法应该帮助临床医生系统地回顾和评价已发表的综述,并帮助基于证据的临床决策。
Hundreds of studies of maternity care interventions have been published, too many for most people involved in providing maternity care to identify and consider when making decisions. It became apparent that systematic reviews of individual studies were required to appraise, summarise and bring together existing studies in a single place. However, decision makers are increasingly faced by a plethora of such reviews and these are likely to be of variable quality and scope, with more than one review of important topics. Systematic reviews (or overviews) of reviews are a logical and appropriate next step, allowing the findings of separate reviews to be compared and contrasted, providing clinical decision makers with the evidence they need. The methods used to identify and appraise published and unpublished reviews systematically, drawing on our experiences and good practice in the conduct and reporting of systematic reviews are described. The process of identifying and appraising all published reviews allows researchers to describe the quality of this evidence base, summarise and compare the review's conclusions and discuss the strength of these conclusions. Methodological challenges and possible solutions are described within the context of (i) sources, (ii) study selection, (iii) quality assessment (i.e. the extent of searching undertaken for the reviews, description of study selection and inclusion criteria, comparability of included studies, assessment of publication bias and assessment of heterogeneity), (iv) presentation of results, and (v) implications for practice and research. Conducting a systematic review of reviews highlights the usefulness of bringing together a summary of reviews in one place, where there is more than one review on an important topic. The methods described here should help clinicians to review and appraise published reviews systematically, and aid evidence-based clinical decision-making.
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