Role of aralar, the mitochondrial transporter of aspartate-glutamate, in brain N-acetylaspartate formation and Ca2+ signaling in neuronal mitochondria
Role of aralar, the mitochondrial transporter of aspartate-glutamate, in brain N-acetylaspartate formation and Ca2+ signaling in neuronal mitochondria
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DOI：
10.1002/jnr.21299
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发表时间：
2007-11-15
影响因子：
4.2
通讯作者：
Pardo, Beatriz
中科院分区：
文献类型：
--
作者：
Satrustegui, Jorgina;Contreras, Laura;Pardo, Beatriz
Aralar是Ca2+依赖性线粒体天冬氨酸-谷氨酸载体，表达于脑和骨骼肌，是苹果酸-天冬氨酸NADH穿梭的一员。破坏老鼠体内的拉拉尔基因SLC25a12，发现了这种载体的两个新作用。一方面，它是脑天冬氨酸和n-乙酰天冬氨酸合成所必需的，n-乙酰天冬氨酸是一种神经元生成的代谢物，为髓磷脂脂合成提供醋酸盐；另一方面，它是通过增加线粒体NADH将小的Ca2+信号传递到线粒体所必需的。(c) 2007 Wiley-Liss, Inc。
Aralar, the Ca2+,-dependent mitochondrial aspartate-glutamate carrier expressed in brain and skeletal muscle, is a member of the malate-aspartate NADH shuttle. Disrupting the gene for aralar, SLC25a12, in mice has enabled the discovery of two new roles of this carrier. On the one hand, it is required for synthesis of brain aspartate and N-acetylaspartate, a neuron-born metabolite that supplies acetate for myelin lipid synthesis; and on the other, it is essential for the transmission of small Ca2+ signals to mitochondria via an increase in mitochondrial NADH. (c) 2007 Wiley-Liss, Inc.