snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma.
snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma.
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DOI：
10.1371/journal.pone.0183410
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Passetti F
中科院分区：
文献类型：
--
作者：
Nogueira Jorge NA;Wajnberg G;Ferreira CG;de Sa Carvalho B;Passetti F
肺癌是世界上最常见的癌症类型之一。大多数患者在晚期被诊断，因此预后不良。吸烟是肺癌的一个危险因素，但大多数吸烟者不会患上肺癌，而20%的肺腺癌女性是非吸烟者。因此，这两个群体除了吸烟状况外，还可能存在差异，包括基因表达特征的差异。非编码RNA在复杂疾病中表达模式的改变使其成为诊断和治疗的潜在生物标志物。我们分析了来自公开的小RNA高通量测序数据的差异和组成型表达的PIWI相互作用RNA和小核仁RNA的数据，以寻找可以区分这两组的非编码RNA的表达模式。在这里，我们报告了两组差异表达的小的非编码RNA在正常和肿瘤组织的妇女肺腺癌，区分吸烟者和非吸烟者。我们的研究结果可能会为烟草引起的代谢改变提供新的见解，并可用于肺癌的早期诊断。
Lung cancer is one of the most frequent types of cancer worldwide. Most patients are diagnosed at advanced stage and thus have poor prognosis. Smoking is a risk factor for lung cancer, however most smokers do not develop lung cancer while 20% of women with lung adenocarcinoma are non-smokers. Therefore, it is possible that these two groups present differences besides the smoking status, including differences in their gene expression signature. The altered expression patterns of non-coding RNAs in complex diseases make them potential biomarkers for diagnosis and treatment. We analyzed data from differentially and constitutively expressed PIWI-interacting RNAs and small nucleolar RNAs from publicly available small RNA high-throughput sequencing data in search of an expression pattern of non-coding RNA that could differentiate these two groups. Here, we report two sets of differentially expressed small non-coding RNAs identified in normal and tumoral tissues of women with lung adenocarcinoma, that discriminate between smokers and non-smokers. Our findings may offer new insights on metabolic alterations caused by tobacco and may be used for early diagnosis of lung cancer.