TRANSLOCATION OF PARTICULATES ACROSS THE GUT WALL - A QUANTITATIVE APPROACH
TRANSLOCATION OF PARTICULATES ACROSS THE GUT WALL - A QUANTITATIVE APPROACH
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DOI：
10.3109/10611869509015948
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发表时间：
1995-01-01
影响因子：
4.5
通讯作者：
DAYAN, AD
中科院分区：
文献类型：
--
作者：
SIMON, L;SHINE, G;DAYAN, AD
测定并量化了乳胶颗粒在大鼠小肠上皮上的易位及其向内脏器官的转移。测定了颗粒吸收率。颗粒从肠腔吸收到内部组织的速度很快，因为在口服给药30分钟内检查的所有组织中都检测到颗粒。在小肠组织中检测到每克组织中颗粒的最大数量。脾、肾、肺、肝和脑组织颗粒数随时间增加而增加，肠系膜淋巴结和心脏组织颗粒数随时间减少而减少。骨髓样本中也检测到颗粒。这些发现表明，该动物模型在评估和量化颗粒摄取以及确定它们被运输到何处的组织方面是有用的。
The translocation of latex particles across the epithelium of the rat small intestine and their transfer to internal organs was determined and quantified. The rate of particle uptake was also established. Particle uptake from the gut lumen to internal tissues was rapid as they were detected in all tissues examined within 30 minutes of oral administration. The maximum number of particles per gram tissue was detected in tissues of the small intestine. Particle number in spleen, kidney, lung, liver and brain increased with time, and in mesenteric lymph node, and heart tissues they decreased with time. Particles were also detected in bone marrow samples.These findings suggest that this animal model is useful in the evaluation and quantification of particle uptake and the determination of the tissues to where they are transported.