Automatic hip abductor muscle fat fraction estimation and association with early OA cartilage degeneration biomarkers.
Automatic hip abductor muscle fat fraction estimation and association with early OA cartilage degeneration biomarkers.
复制标题
自动髋关节外展肌脂肪分数估计及其与早期 OA 软骨退变生物标志物的关联。
DOI：
10.1002/jor.24974
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Majumdar,Sharmila
中科院分区：
文献类型：
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作者：
Tibrewala,Radhika;Pedoia,Valentina;Lee,Jinhee;Kinnunen,Carla;Popovic,Tijana;Zhang,AlanL;Link,ThomasM;Souza,RichardB;Majumdar,Sharmila
本研究的目的是开发髋关节外展肌的自动分割方法，并发现其脂肪含量与早期髋关节骨关节炎（OA）软骨退变生物标志物的关联。这项机构审查委员会批准的、符合《健康保险可移植性和责任法案》的前瞻性研究招募了61名有髋关节OA或股髋臼撞击（FAI）证据的患者。获取磁共振（MR）图像进行软骨分割，计算t1 ρ和t2松弛时间，并对软骨病变评分进行分级。3D V‐Net （Dice loss， Adam优化器，学习率= 1e−4，批大小= 3）被训练分割三块肌肉（臀中肌、臀小肌和阔筋膜张肌）。使用Dice，手动和自动掩膜之间的距离图以及脂肪分数和体积的Bland - Altman图来测量V - Net性能。使用基于体素的松弛测量法（VBR）发现肌肉脂肪分数与T1ρ， t2松弛时间值之间存在关联。Ap< 0.05被认为是显著的。V‐Net的Dice分别为0.90、0.88和0.91 （GMed、GMin和TFL）。VBR结果发现，早期OA和FAI患者的所有三块肌肉的脂肪比例与T1ρ， t2放松时间有关。使用自动的、经过验证的分割模型，OA生物标志物和肌肉脂肪组分之间的关联提供了OA发生的早期变化的见解，并表明髋关节外展肌脂肪与软骨退变标志物相关。
The aim of this study was to develop an automatic segmentation method for hip abductor muscles and find their fat fraction associations with early stage hip osteoarthritis (OA) cartilage degeneration biomarkers. This Institutional Review Board approved, Health Insurance Portability and Accountability Act compliant prospective study recruited 61 patients with evidence of hip OA or Femoroacetabular Impingement (FAI). Magnetic resonance (MR) images were acquired for cartilage segmentation, T1ρand T2relaxation times computation and grading of cartilage lesion scores. A 3D V‐Net (Dice loss, Adam optimizer, learning rate = 1e−4, batch size = 3) was trained to segment the three muscles (gluteus medius, gluteus minimus, and tensor fascia latae). The V‐Net performance was measured using Dice, distance maps between manual and automatic masks, and Bland‐Altman plots of the fat fractions and volumes. Associations between muscle fat fraction and T1ρ, T2relaxation times values were found using voxel based relaxometry (VBR). Ap< 0.05 was considered significant. The V‐Net had a Dice of 0.90, 0.88, and 0.91 (GMed, GMin, and TFL). The VBR results found associations of fat fraction of all three muscles in early stage OA and FAI patients with T1ρ, T2relaxation times. Using an automatic, validated segmentation model, the associations derived between OA biomarkers and muscle fat fractions provide insight into early changes that occur in OA, and show that hip abductor muscle fat is associated with markers of cartilage degeneration.