Detemir insulin for the treatment of diabetes mellitus in dogs
Detemir insulin for the treatment of diabetes mellitus in dogs
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DOI：
10.2460/javma.247.1.73
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发表时间：
2015-07-01
影响因子：
1.9
通讯作者：
Reusch, Claudia E.
中科院分区：
文献类型：
--
作者：
Fracassi, Federico;Corradini, Sara;Reusch, Claudia E.
目的-研究地特胰岛素对糖尿病犬的作用。设计-前瞻性、非对照临床试验。动物-10只患有自然发生的糖尿病的客户拥有的犬。程序-每12小时用地特胰岛素SC治疗犬6个月。随访评估在1，2，4，12，和24周，包括临床体征和血糖浓度曲线和血清果糖胺concentration.Results-Insulin地特胰岛素给药的测量进行了评价导致在6个月的血糖和血清果糖胺浓度显着下降，与预处理值相比。研究结束时的中位胰岛素剂量为0.12 U/kg（0.055 U/lb;范围：0.05 - 0.34 U/kg [0.023 - 0.155 U/lb]，SC，q 12 h）。在22%（10/45）的血糖浓度曲线中发现低血糖，4只犬记录到6次临床低血糖发作。在6个月研究期间，在所有犬中观察到临床体征的主观改善。根据临床体征和血糖浓度曲线，研究结束时地特胰岛素的疗效被认为在5只犬中良好，在3只犬中中度，在2只犬中差。结论和临床相关性-结果表明，每12小时SC注射地特胰岛素可能是治疗犬糖尿病的可行方法。地特胰岛素剂量低于维持血糖控制所需的其他胰岛素类型的报告剂量，表明地特胰岛素应谨慎使用，尤其是在小型犬中。
Objective-To investigate the effects of insulin detemir in dogs with diabetes mellitus.Design-Prospective, uncontrolled clinical trial.Animals-10 client-owned dogs with naturally occurring diabetes mellitus.Procedures-Dogs were treated with insulin detemir SC every 12 hours for 6 months. Follow-up evaluations were done at 1, 2, 4, 12, and 24 weeks and included evaluation of clinical signs and measurement of blood glucose concentration curves and serum fructosamine concentrations.Results-Insulin detemir administration resulted in a significant decrease in blood glucose and serum fructosamine concentrations at 6 months, compared with pretreatment values. Median insulin dosage at the end of the study was 0.12 U/kg (0.055 U/lb; range, 0.05 to 0.34 U/kg [0.023 to 0.155 U/lb], SC, q 12 h). Hypoglycemia was identified in 22% (10/45) of the blood glucose concentration curves, and 6 episodes of clinical hypoglycemia in 4 dogs were recorded. A subjective improvement in clinical signs was observed in all dogs during the 6-month study period. On the basis of clinical signs and blood glucose concentration curves, efficacy of insulin detemir at the end of the study was considered good in 5 dogs, moderate in 3, and poor in 2.Conclusions and Clinical Relevance-Results suggested that SC injection of insulin detemir every 12 hours may be a viable treatment for diabetes mellitus in dogs. Insulin detemir dosages were lower than reported dosages of other insulin types needed to maintain glycemic control, suggesting that insulin detemir should be used with caution, especially in small dogs.