Lipidome Abnormalities and Cardiovascular Disease Risk in HIV Infection
Lipidome Abnormalities and Cardiovascular Disease Risk in HIV Infection
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DOI：
10.1007/s11904-019-00442-9
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发表时间：
2019-06-01
影响因子：
4.6
通讯作者：
Funderburg, Nicholas T.
中科院分区：
文献类型：
--
作者：
Bowman, Emily;Funderburg, Nicholas T.
人类免疫缺陷病毒（HIV）感染及其抗逆转录病毒治疗（ART）与脂质异常相关，可能增加心血管疾病（CVD）的风险。慢性炎症在HIV+个体中持续存在，脂质和炎症之间存在复杂的关系，因为免疫激活可能是HIV感染中脂质异常的原因和结果。基于质谱技术的进步现在允许对单个脂质种类进行详细测量；与传统评估相比，改进的脂质测量可能更好地评估心血管疾病的风险。脂质组学分析已经开始表征HIV感染期间和抗逆转录病毒治疗后脂质组成的动态变化，进一步的研究可能会发现新的脂质生物标志物，预测不良后果。制定策略来改善HIV+人群合并症的管理是很重要的，他汀类药物治疗和生活方式的改变，包括饮食和运动，可能有助于改善血脂水平和降低心血管疾病的风险。
Purpose of ReviewHuman immunodeficiency virus (HIV) infection and its treatment with antiretroviral therapy (ART) are associated with lipid abnormalities that may enhance cardiovascular disease risk (CVD).Recent FindingsChronic inflammation persists in HIV+ individuals, and complex relationships exist among lipids and inflammation, as immune activation may be both a cause and a consequence of lipid abnormalities in HIV infection. Advances in mass spectrometry-based techniques now allow for detailed measurements of individual lipid species; improved lipid measurement might better evaluate CVD risk compared with the prognostic value of traditional assessments.SummaryLipidomic analyses have begun to characterize dynamic changes in lipid composition during HIV infection and following treatment with ART, and further investigation may identify novel lipid biomarkers predictive of adverse outcomes. Developing strategies to improve management of comorbidities in the HIV+ population is important, and statin therapy and lifestyle modifications, including diet and exercise, may help to improve lipid levels and mitigate CVD risk.