Role of glia-derived cholesterol in synaptogenesis:: new revelations in the synapse-glia affair
Role of glia-derived cholesterol in synaptogenesis:: new revelations in the synapse-glia affair
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DOI：
10.1016/s0928-4257(02)00014-1
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发表时间：
2002-04-01
影响因子：
--
通讯作者：
Pfrieger, FW
中科院分区：
文献类型：
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作者：
Göritz, C;Mauch, DH;Pfrieger, FW
大脑的发育和功能依赖于神经元和神经胶质细胞之间的信号交换。在这里，我们回顾了一系列最近的研究纯化的视网膜神经节细胞（RGC）的文化，指出了新的作用，神经胶质细胞的突触连接的形成和可塑性。结果表明，神经元必须通过脂蛋白输入胶质源性胆固醇，以形成大量有效的突触连接。这一发现可以解释为什么在整个中枢神经系统（CNS）的突触发生的主要阶段开始同步胶质细胞分化后，为什么星形胶质细胞产生载脂蛋白E（apoE）和含胆固醇的脂蛋白。这些假设的实验测试可能会进一步我们的理解，在大脑中的胆固醇代谢，并可能有助于解释神经系统症状所造成的胆固醇和脂蛋白代谢缺陷。(C)2002爱思唯尔科技有限公司版权所有。
Brain development and function relies on the exchange of signals between neurons and glial cells. Here we review a series of recent studies on cultures of purified retinal ganglion cells (RGCs) that point to a new role of glial cells in the formation and plasticity of synaptic connections. The results suggest that neurons must import glia-derived cholesterol via lipoproteins to form numerous and efficient synaptic connections. This finding may explain why throughout the central nervous system (CNS) the main phase of synaptogenesis starts synchronously after glia differentiation and why astrocytes produce apolipoprotein E (apoE) and cholesterol-containing lipoproteins. Experimental tests of these hypotheses may further our understanding of the cholesterol metabolism in the brain and may help to explain neurologic symptoms resulting from defective cholesterol and lipoprotein metabolism. (C) 2002 Elsevier Science Ltd. All rights reserved.