Improving precision surgery: A review of current intraoperative nerve tissue fluorescence imaging.
Improving precision surgery: A review of current intraoperative nerve tissue fluorescence imaging.
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DOI：
10.1016/j.cbpa.2023.102361
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发表时间：
2023-07
影响因子：
7.8
通讯作者：
Lei G. Wang;Summer L. Gibbs
中科院分区：
文献类型：
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作者：
Lei G. Wang;Summer L. Gibbs
医源性神经损伤是最令人担心的手术并发症之一，并且仍然是许多外科专业的主要发病率。目前，尚无临床批准的技术可以直接增强术中神经可视化，即使是经验丰富的外科医生，术中神经识别仍然面临着挑战。荧光引导手术（FGS）已成功融入临床医学，以提高手术领域的安全性和有效性。许多组织和疾病特异性造影剂正在临床转化管道中，以供未来 FGS 整合。在此背景下，开发了多种荧光示踪剂来改善外科医生的术中视力。本综述旨在传达神经特异性 FGS 的最新进展及其临床转化潜力。
Iatrogenic nerve injury represents one of the most feared surgical complications and remains a major morbidity across many surgical specialties. Currently, no clinically approved technique can directly enhance intraoperative nerve visualization, where intraoperative nerve identification continues to challenge even experienced surgeons. Fluorescence-guided surgery (FGS) has been successfully integrated into clinical medicine to improve safety and efficacy in the surgical arena. A number of tissue- and disease-specific contrast agents are in the clinical translation pipeline for future FGS integration. Within this context, a diverse repertoire of fluorescent tracers have been developed to improve surgeons’ intraoperative vision. This review aims to convey the recent developments for nerve-specific FGS and its potential for clinical translation.