The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of fibrotic disorders
The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of fibrotic disorders
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DOI：
10.1160/th08-11-0726
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发表时间：
2009-04-01
影响因子：
6.7
通讯作者：
Strieter, Robert M.
中科院分区：
文献类型：
--
作者：
Keeley, Ellen C.;Mehrad, Borna;Strieter, Robert M.
纤维细胞是骨髓来源的间充质祖细胞，表达白细胞、造血祖细胞和成纤维细胞的标记物。它们在生理和病理环境中的组织重塑和纤维化中发挥着关键作用。纤维细胞的独特之处在于它们能够分化成成纤维细胞和肌成纤维细胞以及脂肪细胞。在这篇综述中，我们将提供支持它们在肺、心脏和脉管系统慢性炎症纤维化疾病发病机制中发挥关键作用的数据。
Fibrocytes are bone marrow-derived mesenchymal progenitor cells that express markers of leukocytes, haematopoietic progenitor cells, and fibroblasts. They play a pivotal role in tissue remodelling and fibrosis in both physiologic and pathologic settings. Fibrocytes are unique in that they are capable of differentiating into fibroblasts and myofibroblasts, as well as adipocytes. In this review we will present data supporting the critical role they play in the pathogenesis of chronic inflammatory fibrotic diseases of the lungs, heart and vasculature.