Biomarkers of Ovarian Reserve-Do They Predict Somatic Aging?
Biomarkers of Ovarian Reserve-Do They Predict Somatic Aging?
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DOI：
10.1055/s-0033-1356480
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发表时间：
2013-11-01
影响因子：
2.7
通讯作者：
Cedars, Marcelle I.
中科院分区：
文献类型：
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作者：
Cedars, Marcelle I.
更年期虽然是生育的结束，但也是所有妇女生活中一个主要的荷尔蒙、心理和生理事件。一些研究表明绝经年龄和长寿之间存在联系。此外，一般衰老的细胞和分子机制已被认为在卵巢衰老中起着至关重要的作用。在识别这些相似的生理参数的同时，卵巢年龄的标志物，也被称为卵巢储备，已经被开发出来。这些标志物可以预测绝经年龄，并确定妇女的风险增加，提前绝经，也许先进的身体老化。如果卵巢储备功能下降与长期健康风险增加相关，识别这些女性的能力将至关重要。因此，了解卵巢衰老，特别是早期卵巢衰老是否会使女性面临长期健康问题的风险，并增加发病率和死亡率至关重要。许多研究回顾支持绝经和绝经前变化之间的关联，这些变化与卵巢储备减少、心血管风险、骨质流失以及情绪和认知变化一致。只有纵向研究才能证实任何确定的关联是否反映了因果关系或共同的潜在风险，但现有数据表明，卵巢储备减少的女性代表了一个独特的群体，可能会增加长期健康影响的风险。
Menopause, while the end of reproduction, also represents a major hormonal, psychological and physiological event in the lives of all women. Several studies have suggested an association between the age of menopause and longevity. Additionally, cellular and molecular mechanisms of general aging have been suggested to play a vital role in ovarian aging. In parallel with the recognition of these similar physiological parameters, markers of ovarian age, also known as ovarian reserve, have been developed. These markers may allow prediction of age of menopause and the identification of women at increased risk for earlier menopause, and perhaps advanced somatic aging. The ability to identify these women would be critically important if decreased ovarian reserve were associated with increased long-term health risks. Thus, it is critical to understand if ovarian aging, and particularly, early ovarian aging, would place women at risk for long-term health issues with increased morbidity and mortality. Numerous studies reviewed support an association between menopause, and premenopausal changes consistent with diminish ovarian reserve, and cardiovascular risk, bone loss and changes in mood and cognition. Only longitudinal studies will be able to confirm if any identified associations reflect causality or common underlying risk, but the available data suggest women with diminished ovarian reserve represent a unique group that may be at increased risk for long-term health effects beyond fertility loss.