Aging specifically impairs amnesiac-dependent memory in Drosophila
Aging specifically impairs amnesiac-dependent memory in Drosophila
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DOI：
10.1016/s0896-6273(03)00732-3
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发表时间：
2003-12-04
期刊：
影响因子：
16.2
通讯作者：
Saitoe, M
中科院分区：
文献类型：
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作者：
Tamura, T;Chiang, AS;Saitoe, M
与年龄相关的记忆损害(AMI)在许多物种中都能观察到。然而，目前还不确定急性心肌梗死是由记忆过程中的特定衰退还是非特定衰退引起的。在果蝇中，通过单一嗅觉条件反射范式获得的记忆有三个不同的阶段：短期记忆(STM)、中期记忆(MTM)和较长时间的麻醉抵抗记忆(ARM)。在这里，我们证明了与年龄相关的嗅觉记忆缺陷与MTM突变型遗忘症(AMN)相同。此外，与其他记忆突变体相比，AMN果蝇不会表现出年龄相关的记忆力下降。AMN果蝇中没有急性心肌梗死是通过主要在DPM细胞中表达AMN转基因来恢复的。因此，我们认为果蝇的急性心肌梗死是由于AMN依赖的MTM的特异性减少所致。
Age-related memory impairment (AMI) is observed in many species. However, it is uncertain whether AMI results from a specific or a nonspecific decay in memory processing. In Drosophila, memory acquired after a single olfactory conditioning paradigm has three distinct phases: short-term memory (STM), middle-term memory (MTM), and longer-lasting anesthesia-resistant memory (ARM). Here, we demonstrate that age-related defects in olfactory memory are identical to those of the MTM mutant amnesiac (amn). Furthermore, amn flies do not exhibit an age-dependent decrease in memory, in contrast to other memory mutants. The absence of AMI in amn flies is restored by expression of an amn transgene predominantly in DPM cells. Thus, we propose that AMI in flies results from a specific decrease in amn-dependent MTM.