Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?
Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?
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DOI：
10.1016/j.cell.2010.11.016
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发表时间：
2010-11-24
期刊：
影响因子：
64.5
通讯作者：
Tcherpakov, Marianna
中科院分区：
文献类型：
--
作者：
Cohen, Philip;Tcherpakov, Marianna
蛋白质磷酸化和蛋白质泛素化调控细胞生命的大部分方面，而这些调控机制的缺陷会导致癌症和许多其他疾病。在过去的十年里，蛋白激酶已经成为制药行业最重要的药物靶点之一。相比之下，针对泛素系统组件的药物发现计划已经落后。在这个视角下，我们讨论了这一流水线延迟的原因，已经开发的针对泛素系统的药物，以及未来可能普及这一药物发现领域的新方法。
Protein phosphorylation and protein ubiquitination regulate most aspects of cell life, and defects in these control mechanisms cause cancer and many other diseases. In the past decade, protein kinases have become one of the most important classes of drug targets for the pharmaceutical industry. In contrast, drug discovery programs that target components of the ubiquitin system have lagged behind. In this Perspective, we discuss the reasons for the delay in this pipeline, the drugs targeting the ubiquitin system that have been developed, and new approaches that may popularize this area of drug discovery in the future.