Effect of daily treadmill running exercise on masseter muscle nociception associated with social defeat stress in mice
Effect of daily treadmill running exercise on masseter muscle nociception associated with social defeat stress in mice
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DOI：
10.1111/eos.12882
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发表时间：
2022-07-17
影响因子：
1.9
通讯作者：
Okamoto，Keiichiro
中科院分区：
文献类型：
--
作者：
Hasegawa，Mana;Piriyaprasath，Kajita;Okamoto，Keiichiro
我们研究了社交失败压力 (SDS) 和跑步机跑步对咬肌伤害感受的影响，并通过雄性小鼠口面部福尔马林试验以及上颈脊髓 (C1/C2) 区域的 c-Fos 和 FosB 免疫反应性进行量化。经过 10 天的每日 SDS 或非 SDS 调理后，SDS 调理的小鼠被分为 SDS 敏感小鼠和复原小鼠。选择几只小鼠，包括非 SDS 调理小鼠、SDS 敏感小鼠和弹性小鼠，在第 11 天评估咬肌伤害感受。与非 SDS 小鼠和弹性小鼠相比，10 天的 SDS 调理增加了 SDS 易感小鼠的咬肌诱发的伤害行为以及 c-Fos 和 FosB 表达。其余的 SDS 易感小鼠和非 SDS 小鼠在第 21 天评估咬肌伤害感受之前，再进行 10 天的 SDS 加跑步机跑步或静坐训练。每日跑步训练可减少 SDS 易感小鼠的咬肌伤害感受增强，但对非 SDS 小鼠没有影响。在第 11 天评估每次 SDS 调理 10 天后立即在跑步机上跑步对口面部伤害行为的预防效果。每日 SDS 后立即在跑步机上跑步可抑制增强的口面部伤害行为。这些发现表明，重复的 SDS 会增加咬肌的伤害感受，这可以通过每天在跑步机上跑步锻炼来预防。
We investigated the effects of social defeat stress (SDS) and treadmill running on masseter muscle nociception, which was quantified by the orofacial formalin test and c‐Fos and FosB immunoreactivities in the upper cervical spinal cord (C1/C2) region in male mice. After daily SDS or non‐SDS conditioning for 10 days, SDS‐conditioned mice were categorized into SDS‐susceptible versus resilient mice. Several mice, including non‐SDS‐conditioned, SDS‐susceptible, and resilient mice, were selected to assess masseter muscle nociception on Day 11. SDS conditioning for 10 days increased masseter muscle‐evoked nocifensive behaviors and c‐Fos and FosB expression in SDS‐susceptible compared to non‐SDS and resilient mice. The remaining SDS‐susceptible and non‐SDS mice were subjected to an additional 10 days of SDS plus treadmill running or sedentary sessions before assessing masseter muscle nociception on Day 21. Daily treadmill running sessions reduced enhanced masseter muscle nociception in SDS‐susceptible mice but not in non‐SDS mice. The preventive effects of daily treadmill running immediately after each SDS conditioning for 10 days on orofacial nocifensive behaviors were assessed on Day 11. Treadmill running conducted immediately after daily SDS inhibited enhanced orofacial nocifensive behaviors. These findings indicate that repeated SDS increases masseter muscle nociception, which could be prevented by daily treadmill running exercise.