Assembly In Vitro of Tau Protein and its Implications in Alzheimer's Disease
Assembly In Vitro of Tau Protein and its Implications in Alzheimer's Disease
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DOI：
10.2174/1567205043332207
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发表时间：
2004-05-01
影响因子：
2.1
通讯作者：
Hernandez, Felix
中科院分区：
文献类型：
--
作者：
Avila, Jesus;Perez, Mar;Hernandez, Felix
Tau是一种微管相关蛋白，也是异常细丝的主要成分，这些异常细丝形成异常结构，如阿尔茨海默病患者大脑中发现的神经纤维丝或神经纤维缠结。通过使用高浓度的tau蛋白或在较低的蛋白浓度下，通过添加一些化合物如聚阴离子、脂肪酸（和衍生物）等，可以在体外再现tau异常丝的组装。在这篇小型综述中，总结了体外tau聚合所需的不同条件的描述性分析。
Tau is a microtubule associated protein that is also the main component of the aberrant filaments that form aberrant structures like the neuropil threads or the neurofibrillary tangles, found in the brain of Alzheimer's disease patients. The assembly of tau aberrant filaments could be reproduced in vitro by using a high concentration of tau protein or, at lower protein concentrations, by adding some compounds like polyanions, fatty acids (and derivates), and others. In this mini-review a descriptive analysis of the different conditions needed for in vitro tau polymerization are summarized.