Enhancing task fMRI preprocessing via individualized model-based filtering of intrinsic activity dynamics.
Enhancing task fMRI preprocessing via individualized model-based filtering of intrinsic activity dynamics.
复制标题
通过基于个性化模型的内在活动动力学过滤来增强fMRI预处理fMRI预处理。
DOI:
10.1016/j.neuroimage.2021.118836
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发表时间:
2022-02-15
期刊:
影响因子:
5.7
通讯作者:
Braver, Todd S.
中科院分区:
文献类型:
--
作者:
Singh, Matthew F.;Wang, Anxu;Cole, Michael;Ching, ShiNung;Braver, Todd S.
关键词:
Brain responses recorded during fMRI are thought to reflect both rapid, stimulus-evoked activity and the propagation of spontaneous activity through brain networks. In the current work, we describe a method to improve the estimation of task-evoked brain activity by first “filtering-out” the intrinsic propagation of pre-event activity from the BOLD signal. We do so using Mesoscale Individualized NeuroDynamic (MINDy) models built from individualized resting-state data to subtract the propagation of spontaneous activity from the task-fMRI signal (MINDy-based Filtering). After filtering, time-series are analyzed using conventional techniques. Results demonstrate that this simple operation significantly improves the statistical power and temporal precision of estimated group-level effects. Moreover, use of MINDy-based filtering increased the similarity of neural activation profiles and prediction accuracy of individual differences in behavior across tasks measuring the same construct (cognitive control).Thus, by subtracting the propagation of previous activity, we obtain better estimates of task-related neural effects.
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