Early detection of bipolar disorder: a pilot familial high-risk study of parents with bipolar disorder and their adolescent children
Early detection of bipolar disorder: a pilot familial high-risk study of parents with bipolar disorder and their adolescent children
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DOI：
10.1111/j.1399-5618.2006.00329.x
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发表时间：
2006-08-01
影响因子：
5.4
通讯作者：
Bentall, Richard
中科院分区：
文献类型：
--
作者：
Jones, Steven Huntley;Tai, Sara;Bentall, Richard
目的：在双相情感障碍（BD）的认知，情感，睡眠和活动的障碍已被确定，但鲜为人知的是，这些因素在病情的发展可能发挥的作用。我们研究了这些变量在一个家族性的高风险sample.Methods：25名儿童（13 - 19岁）的双相父母进行了比较，22个年龄和性别匹配的健康对照组的年龄相仿的儿童。参与者使用情感障碍和精神分裂症-终身版本（SADS-L）的时间表进行评估，并完成功能失调的态度，行为抑制/激活，社会节奏，应对方式和睡眠的主观体验的自我报告措施。儿童完成了7天的记录活动（睡眠和活动）和7天的日记测量自尊，积极和消极的影响和反应积极和消极的events.Results：五十六百分之儿童的双相父母（CBP）的情绪症状相比，9%的儿童的控制父母（CC）。CBP组的应对方式和不稳定的自尊与异常的情绪调节策略相一致。两组在睡眠指标上也有差异。观察到的大多数差异是CBP与当前或过去的情绪诊断和CC之间的差异。BD父母报告功能失调的应对方式和（在较小程度上）中断的活动patterns. Conclusions：一个家庭的高风险战略，研究心理因素在BD的作用是可行的和翔实的。这项初步研究表明，异常的应对方式，不稳定的自尊和睡眠失调可能是双相情感障碍的早期标志。然而，目前的研究结果需要进一步探讨纵向研究，以澄清哪些潜在的标志物是真正的预测BD。
Objectives: Disturbances in cognition, affect, sleep and activity have been identified in bipolar disorder (BD) but little is known about the possible role of these factors in the development of the condition. We studied these variables in a familial high-risk sample.Methods: Twenty-five children (13-19 years) of bipolar parents were compared with 22 similar aged children of age- and sex-matched healthy controls. Participants were assessed using Schedule for Affective Disorders and Schizophrenia-Lifetime version (SADS-L) and completed self-report measures of dysfunctional attitudes, behavioural inhibition/activation, social rhythms, coping styles and subjective experience of sleep. Children completed a 7-day recording of actigraphy (sleep and activity) and a 7-day diary measuring self-esteem, positive and negative affect and reactions to positive and negative events.Results: Fifty-six per cent of children of bipolar parents (CBP) reported mood symptoms compared to 9% of children of control parents (CC). The CBP group had coping styles and instability of self-esteem consistent with abnormal strategies for regulating affect. Both groups also differed on sleep measures. The majority of differences observed were between CBP with a current or past mood diagnosis and CC. BD parents reported dysfunctional coping styles and (to a lesser extent) disrupted activity patterns.Conclusions: A familial high-risk strategy for studying the role of psychological factors in BD is feasible and informative. This pilot study indicates that abnormal coping styles, instability of self-esteem and dysregulation of sleep may be early markers of bipolar illness. However, current findings need to be explored further in longitudinal studies to clarify which potential markers are truly predictive of BD.