Sennoside A drug capped biogenic fabrication of silver nanoparticles and their antibacterial and antifungal activities
Sennoside A drug capped biogenic fabrication of silver nanoparticles and their antibacterial and antifungal activities
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DOI：
10.1016/j.jsps.2020.07.003
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发表时间：
2020-08-01
影响因子：
4.1
通讯作者：
Aazam, Elham Shafik
中科院分区：
文献类型：
--
作者：
Al-Ghamdi, Areej Dhawi;Zaheer, Zoya;Aazam, Elham Shafik
番泻苷A（二蒽酮苷）具有通便作用，被用作民间传统药物。以番泻苷A为还原剂和封端剂，首次在室温下合成了番泻苷A封端的银纳米粒子（Ag/番泻苷A）。结果表明，番泻苷A纯品的吸收峰位于266和340 nm处，随着番泻苷A浓度的增加，吸收峰红移至304和354 nm。加入Ag+离子后，在398 nm处还观察到另外的峰，表明形成了球形番泻苷A封端的银纳米颗粒（Ag/番泻苷A）。以十六烷基三甲基溴化铵（CTAB）为稳定剂，研究了阳离子胶束对银/番泻苷A纳米粒成核和生长过程的影响。使用2，2-二苯基-1-苦基肼基氮自由基（DPPH Greek ano teleia）、两种细菌菌株（金黄色葡萄球菌（Staphylococcus aureus）和大肠杆菌（Escherichia coli））和两种酵母菌菌株（白色念珠菌（Candida albicans）ATCC 10231和近平滑念珠菌（Candida parapsilosis）ATCC 22019）来测定Ag/番泻苷A纳米粒的抗氧化和抗微生物性质。此外，从番泻苷A的糖苷键酸水解中分离得到大黄酸-9-蒽酮（4，5-二羟基-10-氧代-9H-蒽-2-羧酸酯），并对其结构进行了表征。大黄酸-9-蒽酮对DPPH自由基、抗细菌和抗真菌菌的抗氧化活性和抑菌活性也进行了测定。测定了最低抑菌浓度并进行了讨论。(C)2020年，任作家。由Elsevier B. V.代表沙特国王大学出版。这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
Sennoside A (dianthrone glycoside) shows laxative properties and used as a folk traditional medicine. Sennoside A capped silver nanoparticles (Ag/sennoside A) were synthesized at room temperature for the first time by using sennoside A as reducing and capping agent. UV-visible spectroscopic data reveals that the absorption peaks of pure sennoside A was appeared at 266, and 340 nm, which red shifted to 304, and 354 nm at higher sennoside A concentration. Upon addition of the Ag+ ions, an additional peak also observed at 398 nm, indicating the formation of spherical sennoside A capped silver nanoparticles (Ag/ sennoside A). Cetyltrimethylammonium bromide (CTAB) was used a stabilizing agent to determine the role of cationic micelles on the nucleation and growth processes of Ag/sennoside A NPs formation. The 2,2-diphenyl-1-picrylhydrazyl nitrogen radical (DPPHGreek ano teleia), two bacteria strains (Staphylococcus aureus and Escherichia coli) and two yeast strains (Candida albicans ATCC 10231 and Candida parapsilosis ATCC 22019) were used to determine the antioxidant and antimicrobial properties of Ag/sennoside A NPs. In addition, Rhein-9-anthrone (4,5-dihydroxy-10-oxo-9H-anthracene-2-carboxylate) was isolated from the acidic hydrolysis of glycoside linkage of sennoside A and characterized. The antioxidant and antimicrobial activities of rhein-9-anthrone were also determined against DPPH radical, antibacterial and antifungal strains. The minimum inhibitory concentration was determined and discussed. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).