Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
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DOI：
10.1126/science.280.5368.1455
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发表时间：
1998-05-29
期刊：
影响因子：
56.9
通讯作者：
Harland, RM
中科院分区：
文献类型：
--
作者：
Brunet, LJ;McMahon, JA;Harland, RM
Noggin是一种骨形态发生蛋白（BMP）拮抗剂，在Spemann's组织者中表达。小鼠Noggin在凝缩软骨和未成熟软骨细胞中表达，许多bmp也是如此。在缺乏Noggin的小鼠中，软骨凝聚正常启动，但增生，通过生长分化因子-5的表达测量，关节发育启动失败。软骨的成熟和Herd表达不受影响。在没有Noggin拮抗作用的情况下，BMP活性过剩可能会促进细胞向软骨的募集，导致生长板过大；软骨细胞对诱导关节的位置信号也不敏感。
Noggin is a bone morphogenetic protein (BMP) antagonist expressed in Spemann's organizer. Murine Noggin is expressed in condensing cartilage and immature chondrocytes, as are many BMPs. In mice lacking Noggin, cartilage condensations initiated normally but developed hyperplasia, and initiation of joint development failed as measured by the expression of growth and differentiation factor-5. The maturation of cartilage and Herd expression were unaffected. Excess BMP activity in the absence of Noggin antagonism may enhance the recruitment of cells into cartilage, resulting in oversized growth plates; chondrocytes are also refractory to joint-inducing positional cues.