CENTRAL TARGET FOR THE BEHAVIORAL-EFFECTS OF VASOPRESSIN NEUROPEPTIDES
CENTRAL TARGET FOR THE BEHAVIORAL-EFFECTS OF VASOPRESSIN NEUROPEPTIDES
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DOI：
10.1038/308276a0
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发表时间：
1984-01-01
期刊：
影响因子：
64.8
通讯作者：
DEJONG, W
中科院分区：
文献类型：
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作者：
DEWIED, D;GAFFORI, O;DEJONG, W
神经垂体激素血管加压素发挥抗利尿、血管加压和行为作用（例如，促进记忆过程）1-6。加压素可以通过直接影响大脑过程来改变动物行为2，3，6。然而，最近有人提出，加压素主要作用于外周受体系统，并通过改变内脏传入信号影响行为机制7。我们现在提供的数据显示：（1）[Arg 8]加压素（AVP）和更有效的[pGlu 4，Cyt 6]AVP（4-8）（由脑突触膜8产生的AVP肽的脱甘氨酸酰胺衍生物）的中枢给药产生行为效应（促进被动回避行为）而无升压效应;（2）中枢给药血管加压素拮抗剂可阻断AVP的行为效应，但不能阻断AVP的升压效应;（3）[pGlu 4，Cyt 6]AVP（4-8）在无升压效应的情况下诱导行为效应。结果表明，AVP和相关肽影响被动回避行为的直接中枢作用和激活中枢加压素受体的结构要求不同的外周心血管受体，虽然两者都可以被阻断相同的血管加压素拮抗剂。
The neurohypophysial hormone vasopressin exerts antidiuretic, vasopressor and behavioural effects (for example, facilitation of memory processes)1–6. Vasopressin may alter animal behaviour via direct effect on brain processes2,3,6. Recently, however, it has been suggested that vasopressin acts mainly at peripheral receptor systems and influences behavioural mechanisms by altering visceral afferent signals7. We now present data showing that (1) central administration of [Arg8]vasopressin (AVP) and more potently [pGlu4, Cyt6]AVP(4–8), the desglycinamide derivative of a peptide generated from AVP by brain synaptic membranes8, produce the behavioural effect (promotion of passive avoidance behaviour) without the pressor effect; (2) central administration of a vasopressor antagonist blocks the behavioural but not the pressor effect of systemically administered AVP; and (3) [pGlu4, Cyt6]AVP(4–8) induces the behavioural effect in the absence of the pressor effect. The results indicate that AVP and related peptides affect passive avoidance behaviour by a direct central action and that the structural requirement for activation of central vasopressin receptors differs from that of the peripheral cardiovascular receptors, although both can be blocked by the same vasopressor antagonist.