Cancer treatment effects on cognition and depression: The moderating role of physical activity
Cancer treatment effects on cognition and depression: The moderating role of physical activity
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DOI：
10.1016/j.breast.2019.01.004
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发表时间：
2019-04-01
期刊：
影响因子：
3.9
通讯作者：
Thomas, Gwendolyn A.
中科院分区：
文献类型：
--
作者：
Bedillion, Margaret F.;Ansell, Emily B.;Thomas, Gwendolyn A.
目的：乳腺癌幸存者报告治疗后，特别是化疗后，有明显的认知障碍。抑郁症也可能发生在治疗后，并可能部分介导癌症治疗对认知的影响。此外，体力活动已被证明可以减轻对认知和抑郁的治疗效果。本研究探讨了抑郁症的作用，在介导的癌症治疗对认知功能的影响（认知功能障碍，PCI，认知能力，PCA）在乳腺癌幸存者，并探讨了身体活动在缓和这些effects.Materials and Methods的作用：317乳腺癌幸存者被招募通过军队的妇女。参与者年龄在40-75岁之间，患有0期（原位）至IIIc期乳腺癌，治疗后不到10年。参与者完成了人口统计学和治疗问卷，以及国际体力活动问卷，功能评估癌症治疗认知功能，和流行病学研究中心抑郁Scale.Results：抑郁症状显着有助于认知功能在所有模型。适度和剧烈的体力活动调节乳腺癌治疗对抑郁和认知的影响。化疗，他莫昔芬，和阿那曲唑都表现出负面影响cognition.Conclusion：从这项研究的结果支持检查中介因素的重要性，癌症治疗对认知的影响，特别是抑郁症，癌症治疗后。治疗对乳腺癌幸存者认知的影响部分可以通过抑郁症状的变化来解释，尽管化疗可能会影响认知，而不依赖于抑郁。重要的是，体力活动可以降低乳腺癌幸存者患抑郁症和认知障碍的风险。(C)2019爱思唯尔有限公司版权所有。
Objectives: Breast cancer survivors report significant cognitive impairments post treatment, particularly following chemotherapy. Depression may also occur post treatment and may partially mediate the effects of cancer treatment on cognition. Additionally, physical activity has been shown to mitigate treatment effects on cognition and depression. This study examined the role of depression in mediating the effects of cancer treatment on cognitive function (perceived cognitive impairment, PCI; perceived cognitive ability, PCA) in breast cancer survivors and explored the role of physical activity in moderating these effects.Materials and methods: 317 breast cancer survivors were recruited via Army of Women. Participants were 40-75 years old and had stage 0 (in situ) to IIIc breast cancer and were less than 10 years post treatment. Participants completed a demographic and treatment questionnaire, as well as the International Physical Activity Questionnaire, Functional Assessment of Cancer Therapy-Cognitive Function, and Center for Epidemiologic Studies Depression Scale.Results: Depressive symptoms significantly contributed to cognitive function in all models. Moderate and vigorous levels of physical activity moderated breast cancer treatment effects on depression and cognition. Chemotherapy, tamoxifen, and anastrozole all demonstrated negative effects on cognition.Conclusion: The results from this study support the importance of examining mediating factors in the effects of cancer treatment on cognition, particularly depression, following cancer treatment. Effects of treatment on cognition in breast cancer survivors are partially explained by changes in depressive symptoms, although chemotherapy may impact cognition independent of depression. Importantly, physical activity may reduce the risk of depression and cognitive impairment in breast cancer survivors. (C) 2019 Elsevier Ltd. All rights reserved.