Detailed classification of swimming paths in the Morris Water Maze: multiple strategies within one trial.
Detailed classification of swimming paths in the Morris Water Maze: multiple strategies within one trial.
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DOI：
10.1038/srep14562
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发表时间：
2015-10-01
影响因子：
4.6
通讯作者：
Vasilaki E
中科院分区：
文献类型：
--
作者：
Gehring TV;Luksys G;Sandi C;Vasilaki E
莫里斯水迷宫是啮齿动物空间学习研究中广泛使用的任务。莫里斯水迷宫中动物的经典表现测量包括逃脱潜伏期和到平台的累积距离。其他方法侧重于将轨迹模式分类为代表不同动物策略的刻板类别。然而，这些方法通常将轨迹视为一个整体，因此它们将一个完整的轨迹分配给一个类别，而动物经常在一次试验中在这些策略及其相应的类别之间切换。为此，我们采取了一种不同的方法：我们在一次试验中寻找不同动物行为的片段，并采用半自动分类方法来识别试验中动物表现出的各种策略。我们的方法使我们能够揭示两个动物群体（应激的、非应激的）探索策略的显着且系统的差异，这是早期方法无法观察到的。
The Morris Water Maze is a widely used task in studies of spatial learning with rodents. Classical performance measures of animals in the Morris Water Maze include the escape latency, and the cumulative distance to the platform. Other methods focus on classifying trajectory patterns to stereotypical classes representing different animal strategies. However, these approaches typically consider trajectories as a whole, and as a consequence they assign one full trajectory to one class, whereas animals often switch between these strategies, and their corresponding classes, within a single trial. To this end, we take a different approach: we look for segments of diverse animal behaviour within one trial and employ a semi-automated classification method for identifying the various strategies exhibited by the animals within a trial. Our method allows us to reveal significant and systematic differences in the exploration strategies of two animal groups (stressed, non-stressed), that would be unobserved by earlier methods.