Optical mapping of the spread of excitation in the isolated rat atrium during tachycardia-like excitation
Optical mapping of the spread of excitation in the isolated rat atrium during tachycardia-like excitation
复制标题
心动过速样激发期间离体大鼠心房中激发传播的光学映射
DOI：
--
复制
发表时间：
2003
期刊：
影响因子：
--
通讯作者：
T. Sakai
中科院分区：
文献类型：
--
作者：
T. Sakai
采用电压敏感的部花青-绕丹宁染料NK 2761和多元件光电二极管阵列对膜电位活动进行多位点光学记录，以监测离体大鼠心房制备物中的动作电位。电刺激诱发心动过速样兴奋（TE）事件。通过对光学动作电位的足计时来光学评估兴奋的传导模式，然后制作兴奋传播模式图。兴奋波常围绕包括上级腔静脉口在内的阻塞区旋转。其他模式，如折返无解剖障碍，异位起搏器和更复杂的模式，有时观察到。TE起始期的光学标测表明，传导速度的降低和阻滞区的出现有助于TE的建立。根据TE的特点，认为TE是心房节律的一种亚稳态。TE似乎类似于心房扑动。
Multiple-site optical recording of membrane potential activity, using the voltage-sensitive merocyanine-rhodanine dye NK2761 and a multiple-element photodiode array, was employed to monitor action potentials in an isolated rat atrial preparation. The events of tachycardia-like excitation (TE) were evoked by electrical stimulation. The conduction pattern of excitation was assessed optically by timing the feet of optical action potentials, then maps of excitation spread patterns were made. The excitatory waves often rotated around the blocked area including the ostium of the superior vena cava. Other patterns, such as reentry without anatomical obstacles, ectopic pacemaker and more complex patterns, were sometimes observed. Optical mapping during the initiation phase of TE indicated that the decrease of the conduction velocity and the appearance of blocked areas contributed the establishment of TE. On the basis of the characteristics of TE, it is suggested that TE is a metastable state of atrial rhythm. TE appears to be analogous to atrial flutter.
影响因子：
37.8
作者：
Skanes, AC;Mandapati, R;Jalife, J
通讯作者：
Jalife, J