Bednař Tumor (Pigmented Dermatofibrosarcoma Protuberans)
Bednař Tumor (Pigmented Dermatofibrosarcoma Protuberans)
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Bednař 肿瘤（隆突色素性皮肤纤维肉瘤）
DOI：
10.1111/j.1440-1827.1990.tb01539.x
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
M. Enjoji
中科院分区：
文献类型：
--
作者：
Jian;H. Hashimoto;T. Sugimoto;M. Tsuneyoshi;M. Enjoji
对6例Bednaf肿瘤病例进行了临床病理学分析，沿着对39例已发表病例进行了回顾。并与44例普通型隆突性皮肤纤维肉瘤（DFSP）进行比较。两类肿瘤的临床表现和肿瘤的解剖位置相似，但Bednar肿瘤的复发率较低。Bednar瘤的组织学类型与普通DFSP无明显区别，但可见散在的含黑素小体细胞。超微结构和免疫组化检查显示，没有证据的优势纺锤形细胞在Bednaf肿瘤的神经外胚层分化，支持成纤维细胞的分化线。对黑素小体的起源和发病机制进行了探讨。这些细胞未能与HNIB 45（一种黑色素瘤特异性抗体）反应，并且存在的绝大多数黑色素体是成熟的或处于IV期，加上少数处于II期的不成熟的黑色素体。这些色素细胞似乎不是肿瘤性的，不能作为贝德纳瘤是神经外胚层肿瘤的证据。《病理学学报》Jpn 40：744 - 754，1990年。
Six cases of Bednaf tumor were analyzed clinicopatho‐logically along with a review of 39 published cases. The findings were then compared with data on 44 cases of ordinary dermatofibrosarcoma protuberans (DFSP) obtained from our files. The clinical manifestations of the patients and the anatomic locations of the tumors were similar between the two categories, but the rate of recurrence was lower in cases of Bednar tumor. The histologic pattern of Bednar tumor was indistinguishable from ordinary DFSP except for scattered melanosome containing cells. Ultrastructural and immunohistochemical examinations showed no evidence of neuroectodermal differentiation of dominant spindle shaped cells in Bednaf tumor, supporting a fibroblastic line of differentiation. The origin and pathogenesis of the melanosome containing cells were considered. These cells failed to react with HNIB 45, a melanoma specific antibody, and the large majority of melanosomes present were mature or at Stage IV, plus a few immature ones at Stage II. These pigmented cells do not appear to be neoplastic, and cannot be used as proof to indicate that Bednar tumor is a neuroectodermal neoplasm. Acta Pathol Jpn 40: 744‐754, 1990.