In vivo activity of anprocide alone, and in vitro activity in combination with conventional antibiotics against Staphylococcus aureus and Staphylococcus epidermidis biofilms.
In vivo activity of anprocide alone, and in vitro activity in combination with conventional antibiotics against Staphylococcus aureus and Staphylococcus epidermidis biofilms.
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DOI：
10.1099/jmm.0.008268-0
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发表时间：
2009-09
影响因子：
3
通讯作者：
R. Pettit;C. Weber;Stacey B Lawrence;G. Pettit;M. Kean;G. Cage
中科院分区：
文献类型：
--
作者：
R. Pettit;C. Weber;Stacey B Lawrence;G. Pettit;M. Kean;G. Cage
金黄色葡萄球菌多重耐药的惊人蔓延，加上频繁发生的S。金黄色葡萄球菌和表皮葡萄球菌在生物膜型感染中的应用表明对新疗法的需求日益增长。实验性甾体酰胺雄甾烷杀素[3 β-乙酰氧基-17 β-（l-脯氨酰基）氨基-5 α-雄甾烷]显著降低c.f.u. ml（-1）/缝线（P <0.0001）。金黄色葡萄球菌感染。在棋盘格试验中，金黄色葡萄球菌和对表皮葡萄球菌，抗生素与杆菌肽、苯唑西林、克林霉素或头孢曲松具有协同作用。杀螨剂与杆菌肽或苯唑西林联用对某些生物膜生长的沙门氏菌菌株也有协同作用。金黄色葡萄球菌和表皮。
The alarming spread of multiple drug resistance in Staphylococcus aureus, combined with the frequent occurrence of S. aureus and Staphylococcus epidermidis in biofilm-type infections, indicates a growing need for new therapies. The experimental steroidal amide anprocide [3beta-acetoxy-17beta-(l-prolyl)amino-5alpha-androstane] significantly reduced c.f.u. ml(-1) per suture (P <0.0001) in a murine model of topical S. aureus infection. In chequerboard assays with planktonic-grown S. aureus and S. epidermidis, anprocide was synergistic with bacitracin, oxacillin, clindamycin or ceftriaxone. Anprocide was also synergistic in combination with bacitracin or oxacillin against some isolates of biofilm-grown S. aureus and S. epidermidis.