Dp71, the nonmuscle product of the Duchenne muscular dystrophy gene is associated with the cell membrane
Dp71, the nonmuscle product of the Duchenne muscular dystrophy gene is associated with the cell membrane
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Dp71，杜氏肌营养不良症基因的非肌肉产物，与细胞膜相关
DOI：
10.1016/0014-5793(93)80992-4
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发表时间：
1993
期刊：
影响因子：
3.5
通讯作者：
U. Nudel
中科院分区：
文献类型：
--
作者：
D. Rapaport;D. Greenberg;M. Tal;D. Yaffe;U. Nudel
70.8 kDa蛋白Dp 71是包括脑在内的许多非肌肉组织中主要的杜氏肌营养不良症（DMD）基因产物。Dp 71与肌营养不良蛋白共享大部分C-末端和富含半胱氨酸的结构域，但缺乏血影蛋白样重复序列的整个大杆状结构域和N-末端肌动蛋白结合结构域。Dp 71的功能尚不清楚。使用亚细胞分级和免疫染色，我们表明，Dp 71与质膜。Dp 71还与转染表达Dp 71的载体的mdxmyogenic细胞中的质膜相关。
The 70.8 kDa protein, Dp71, is the major Duchenne muscular dystrophy (DMD) gene product in many nonmuscle tissues including the brain. Dp71 shares most of the C-terminal and cysteine-rich domains with the dystrophins but lacks the entire large rod shaped domain of spectrin-like repeats, and the N-terminal actin-binding domain. The function of Dp71 is unknown. Using subcellular fractionation and immunostaining we show that Dp71 is associated with the plasma membrane. Dp71 is also associated with the plasma membrane inmdxmyogenic cells transfected with a vector expressing Dp71.