Influence of adenosine and lowered cerebral blood flow on the cerebrovascular effects of theophylline.
Influence of adenosine and lowered cerebral blood flow on the cerebrovascular effects of theophylline.
复制标题
腺苷和降低脑血流量对茶碱脑血管作用的影响。
DOI：
10.1016/0014-2999(75)90100-4
复制
发表时间：
1975
影响因子：
5
通讯作者：
R. Zimmer
中科院分区：
文献类型：
--
作者：
G. Oberdörster;R. Lang;R. Zimmer
观察脑血管对动脉灌注茶碱的反应。实验在供体犬的离体犬脑灌注上进行。因此，消除了茶碱引起的继发性影响。动脉pO 2、pCO 2、pH和脑温保持恒定。根据总静脉流出量和脑灌注压计算脑血管阻力（CVR）。在正常脑灌注压（约81 mm Hg）、降低灌注压（约37 mm Hg）和持续10分钟（10− 7 mol/min）的腺苷输注期间，每个脑给予2 mg剂量的茶碱。在正常压力下，茶碱使CVR显著降低15%，但在降低灌注压时，CVR显著增加19%。在输注腺苷期间，CVR降低了23%，茶碱再次使CVR增加了20%，从而证明了edonosine-茶碱拮抗作用。从我们的结果，这表明，腺苷可能参与脑血管舒张缺氧脑。
The responses of brain vessels to theophylline infused intra-arterially was evaluated. The experiments were performed on isolated canine brains perfused by donor dogs. Thus secondary effects due to theophyline were eliminated. Arterial pO2, pCO2, pH and brain temperature were kept constant. Cerebral vascular resistance (CVR) was calculated from total venous outflow and cerebral perfusion pressure. A 2 mg doses of theophylline per brain was given at normal cerebral perfusion pressure (about 81 mm Hg), at lowered perfusion pressure (about 37 mm Hg), and during and adenosine infusion lasting 10 min (10−7mol/min). At normal pressure theophylline showed a significant 15% decrease of CVR, but at lowered perfusion pressure a significant 19% increase occured. During infusion of adenosine, which decreased CVR by 23%, theophylline again increased CVR by 20% thus demonstrating an edonosine-theophylline antagonism. From our results, it is suggested that adenosine could be involved in the vasodilatation of cerebral vessels in the hypoxic brain.