The significance of anti-Mullerian hormone concentration in seminal plasma for spermatogenesis
The significance of anti-Mullerian hormone concentration in seminal plasma for spermatogenesis
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DOI：
10.1093/humrep/17.4.968
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发表时间：
2002-04-01
影响因子：
6.1
通讯作者：
Kamidono, S
中科院分区：
文献类型：
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作者：
Fujisawa, M;Yamasaki, T;Kamidono, S
背景：成年期精浆中抗苗勒氏激素(AMH)的作用尚不清楚。我们检测了精液中AMH在精子发生中的意义。方法：测定39例少精子症患者(平均年龄+/-SD，32.7±-4.3岁)和10例正常人精液中AMH的浓度，以探讨精液中AMH与精子发生的关系。少精子症患者精液AMH浓度(149.3+/-254.0 pmoL/L)显著低于正常男性(249.0+/-167.7 pmoL/L，P+/-0.0337)。精液中AMH浓度与精子密度(r=0.339，P=0.0350)和平均睾丸体积(r=0.440，P=0.246)呈显著正相关。血清促黄体生成素水平(r=-0.365，P=0.0241)与精浆促性腺激素水平呈显著正相关，而与促卵泡刺激素、睾酮、雌二醇无显著相关性。结论：精浆中的AMH可能对精子的产生有重要作用，是支持细胞发育的良好指标。
BACKGROUND: The function of anti-Mullerian hormone (AMH) in seminal plasma in adulthood is uncertain. We examined the significance of seminal AMH for spermatogenesis. METHODS: We measured seminal concentrations of AMH in 39 oligozoospermic men (mean age +/- SD, 32.7 +/- 4.3 years) and 10 normal volunteers to examine the association of seminal AMH with spermatogenesis. The seminal concentrations of AMH in oligozoospermic men (149.3 +/- 254.0 pmol/l) were significantly lower than in normal men (249.0 +/- 167.7 pmol/l, P +/- 0.0337). Seminal AMH concentration correlated significantly with sperm concentration (r = 0.339, P = 0.0350) and mean testicular volume (r = 0.440, P = 0.246). The serum concentration of LH (r = - 0.365, P = 0.0241), but not FSH, testosterone or estradiol, correlated significantly with AMH concentration in seminal plasma. CONCLUSIONS: AMH in seminal plasma may be important for sperm production, and is a good marker for Sertoli cell development.