The Effects of Age and Menopause on Erythrocyte Aggregation
The Effects of Age and Menopause on Erythrocyte Aggregation
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年龄和更年期对红细胞聚集的影响
DOI：
10.1055/s-0038-1655977
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发表时间：
1997
影响因子：
6.7
通讯作者：
S. Dündar
中科院分区：
文献类型：
--
作者：
H. Demiroğlu;Ibrahim Banşta;S. Dündar
亲爱的先生，红细胞聚集（EA）在微循环水平上具有重要作用，并且是动脉粥样硬化病变发展的众所周知的风险因素（1-3）。动脉粥样硬化是一种与年龄相关的退行性过程，男性比绝经前女性更容易发生（4）。根据老年和男性易患动脉粥样硬化病变的知识，出现了一些问题：EA是否随年龄增长而增加？男性EA高于绝经前女性吗？绝经后EA增加吗？考虑到这些问题，我们调查了年龄和绝经是否对EA有影响。健康且年龄和其他致动脉粥样硬化风险因素（胆固醇、动脉血压、吸烟习惯）匹配的64名男性（平均年龄：53 ± 2.9，范围30-81）和62名女性（平均年龄：52 ± 3.2，范围28-78）被纳入研究。这些妇女都没有服用口服避孕药。每个性别组分为两组：A组包括年龄小于50岁的患者，E组包括年龄大于50岁的患者。各组的详细情况如下：（n：33，平均年龄：38 ± 3.1，范围：30-49），男性-B（n：31，平均年龄：62 ± 2.8，范围：51-81），女性-A（n：30，平均年龄：37 ± 3.4，范围：28-48）和女性-B（n：32，平均年龄：63 ± 3.1，范围：52-78）。所有女性A均处于绝经前期，所有女性B均处于绝经期。对于EA测量，将空腹静脉样品收集到用EDTA抗凝的管中，然后通过去除或添加自体血浆将血细胞比容调节至45%。在600 s-1、停滞（M）和3 s-1（M1）剪切后，通过光度流变仪（Myrenne凝集仪）在20 ml血液中进行测量（5）。适当时，使用Student t检验和方差分析进行组间比较。用Pearson相关系数评价数值变量与M和M1的相关性。采用多元回归模型进行多因素分析。所有值均表示为平均值±标准误差。p <0.05的值被认为具有统计学显著性。EA的结果示于表1中。所有组的红细胞压积、纤维蛋白原和胆固醇值相似（p >0：05）。男性中M和M1的EA未随年龄增加而增加（p >0.05，男性A与男性B）。另一方面，绝经后妇女的M和M1值相对于绝经前显著增加（p <0.05，妇女-A vs.妇女-B）。男性组M和M1时的EA值也显著高于女性-A（p <0.05，男性-A和男性-B对女性-A），但与女性-B相当（p >0.05，男性-A和男性-B对女性-B）。在这项研究中，我们研究了高龄和绝经是否是增强EA的独立危险因素。调查这一
Dear Sir, Erythrocyte aggregation (EA) has an important role at the level of microcirculation and is a well known risk factor for the development of atherosclerotic lesions (1-3). Atherosclerosis is an age-related degenerative process with men more prone to it than premenopausal women (4). In the light of the knowledge that old age and male gender predispose to atherosclerotic lesions, some questions arise: Does EA increase with age? Is EA higher in men than premenopausal women? Does EA increase in the postmenopausal period? With these questions in mind we investigated whether age and menopause had an effect on EA. Healthy and matched for age and other atherogenic risk factors (cholesterol, arterial blood pressure, smoking habits), 64 men (mean age: 53 ± 2.9, range 30-81) and 62 women (mean age: 52 ± 3.2, range 28-78) were included into the study. None of the women were receiving oral contraceptive drugs. Each sex group was divided into two: group-A included patients younger than 50 years of age and group-E, older than 50. Details of the groups were as follows: men-A (n: 33, mean age: 38 ± 3.1, range: 30-49), men-B (n: 31, mean age: 62 ± 2.8, range: 51-81), women-A (n: 30, mean age: 37 ± 3.4, range: 28-48) and women-B (n: 32, mean age: 63 ± 3.1, range: 52-78). All women-A were in the premenopausal period and all women-B were in menopause. For EA measurement, fasting venous samples were collected into tubes anticoagulated with EDTA and then haematocrits were adjusted to 45% by removing or adding autologous plasma. Measurements were performed by a photometric rheoscope (Myrenne aggregometer) in 20 ml of blood, after shearing at 600 s-1, at stasis (M) and at 3 s-1 (M1) (5). Student's t-test and analysis of variance were used for comparisons between groups where appropriate. The association of numeric variables with M and M1 were evaluated by Pearson's coefficient. Multivariate analysis was performed by using a multiple regression model. All values were expressed as mean ± standard error. A value of p <0.05 was accepted statistically significant. Results of EA are shown in Table 1. Haematocrit, fibrinogen and cholesterol values were similar in all groups (p >0:05). EA at M and M1 did not increase with age in men (p >0.05, men-A vs. men-B). On the other hand, M and M1 values increased significantly in the postmenopausal women with regard to premenopausal period (p <0.05, women-A vs. women-B). Also EA values at M and M1 were significantly higher in men's groups than women-A (p <0.05, men-A and men-B vs. women-A), but comparable with women-B (p >0.05, men-A and men-B vs. women-B). In this study, we examined whether advanced age and menopause were independent risk factors for an enhanced EA. To investigate this