Cohort profile: the Trivandrum non-alcoholic fatty liver disease (NAFLD) cohort
Cohort profile: the Trivandrum non-alcoholic fatty liver disease (NAFLD) cohort
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DOI：
10.1136/bmjopen-2018-027244
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发表时间：
2019-05-01
期刊：
影响因子：
2.9
通讯作者：
Shenoy, Kotacherry T.
中科院分区：
文献类型：
--
作者：
Chalmers, Jane;Ban, Lu;Shenoy, Kotacherry T.
目的Trivandrum非酒精性脂肪性肝病(NAFLD)队列是一项基于人群的研究，旨在研究印度人群中遗传和生活方式因素之间的相互作用及其与NAFLD风险增加的关系。2013至2016年间，通过多阶段整群抽样，总共2222名参与者被招募到该队列中，Trivandrum是南印度喀拉拉邦的一个地区。数据来自随机选择的25岁以上家庭的所有居民。到目前为止，从2158名参与者中收集了完整的基线临床和病理数据。这包括详细的人口统计资料、人体测量数据和生活方式数据(食物频率、体力活动以及焦虑和抑郁问卷)。进行肝脏生化和超声检查，并采集全血标本进行DNA分析。非酒精性脂肪肝在该人群中的患病率为49.8%，明显高于全球25%的综合患病率。这突显了像这样的强有力的前瞻性研究的重要性，以便能够收集关于风险因素、疾病进展的纵向数据，并促进未来的干预性研究。未来计划从该队列收集的数据的完整分析将为导致印度人群中NAFLD风险如此显著增加的表型和基因特征的相互作用提供有价值的见解。该队列还将构成未来旨在改善肝脏和代谢健康的生活方式干预研究的基础。
Purpose The Trivandrum non-alcoholic fatty liver disease (NAFLD) cohort is a population-based study designed to examine the interaction between genetic and lifestyle factors and their association with increased risk of NAFLD within the Indian population.Participants Between 2013 and 2016, a total of 2222 participants were recruited to this cohort through multistage cluster sampling across the whole population of Trivandrum-a district within the state of Kerala, South India. Data were collected from all inhabitants of randomly selected households over the age of 25.Findings to date Full baseline clinical and pathological data were collected from 2158 participants. This included detailed demographic profiles, anthropometric measures and lifestyle data (food frequency, physical activity and anxiety and depression questionnaires). Biochemical profile and ultrasound assessment of the liver were performed and whole blood aliquots were collected for DNA analysis. The NAFLD prevalence within this population was 49.8% which is significantly higher than the global pooled prevalence of 25%. This highlights the importance of robust, prospective studies like this to enable collection of longitudinal data on risk factors, disease progression and to facilitate future interventional studies.Future plans The complete analysis of data collected from this cohort will give valuable insights into the interaction of the phenotypic and genotypic profiles that result in such a dramatic increased risk of NAFLD within the Indian population. The cohort will also form the basis of future lifestyle interventional studies, aimed at improving liver and metabolic health.