Holding back: HLA-associated inhibition of NK cells gives HIV a leg up.

Holding back: HLA-associated inhibition of NK cells gives HIV a leg up.
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阻碍:HLA 相关的 NK 细胞抑制使 HIV 占据优势。

DOI:
10.1016/j.chom.2022.07.009
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发表时间:
2022
影响因子:
30.3
通讯作者:
Jost,Stephanie
Jost,Stephanie
中科院分区:
医学1区
文献类型:
--
作者:
Jost,Stephanie

文献摘要

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In this issue ofCell Host & Microbe, Li et al. unveil an association between HLA-B∗46:01 and HIV disease progression in Asian populations. The distinct natural killer (NK) cell signature identified in individuals carrying HLA-B∗46:01 strongly suggests that NK cell inhibition plays a role in loss of HIV control.