Appetite-Related Gut Peptides in Obesity and Binge Eating Disorder.
Appetite-Related Gut Peptides in Obesity and Binge Eating Disorder.
复制标题
肥胖和暴饮暴食障碍中与食欲相关的肠肽。
DOI：
10.1177/1559827608317358
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发表时间：
2008-07
影响因子：
1.9
通讯作者：
Aviram-Friedman R
中科院分区：
文献类型：
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作者：
Geliebter A;Ochner CN;Aviram-Friedman R
世界范围内肥胖症流行率的增加是能量正平衡的结果，能量摄入超过支出。肥胖症的饮食行为范围从轻度被动过度消费到过度暴饮暴食，在暴饮暴食症（BED）中观察到失控。在床上控制食欲的信号系统是复杂的，在这一点上，还没有得到很好的理解。本综述强调了目前的知识，肠道肽系统的关键组成部分，并检查证据的缺陷信号，区分肥胖暴食者从肥胖的非暴食者。饥饿、饱腹感和代谢状态的信号网络包括来自能量储存的瘦素和胰岛素以及来自胃肠道的胆囊收缩素、胰高血糖素样肽-1、肽YY（3-36）和胃饥饿素。在许多胃肠道肽中，胃饥饿素是唯一确定的刺激食欲的肽，而胆囊收缩素、胰高血糖素样肽-1和肽YY（3-36）促进饱腹感。脂肪组织通过瘦素和胰岛素向大脑提供有关能量储存的激素信号，可能来自脂联素和胰岛素。暴饮暴食与生长激素释放肽信号系统的功能障碍有关。此外，在BED中观察到的更大的胃容量可能进一步减少饱腹感信号并导致暴饮暴食。
The worldwide increase in obesity prevalence is a result of positive energy balance, with energy intake exceeding expenditure. The eating behavior in obesity ranges from mild passive overconsumption to excessive overeating with loss of control observed in binge eating disorder (BED). The signaling systems that underlie appetite control in BED are complex and, at this point, not well understood. The present review highlights the current knowledge of key components of the gut peptide system and examines evidence of defects in signaling that differentiate obese binge eaters from obese non–binge eaters. The signaling network underlying hunger, satiety, and metabolic status includes leptin and insulin from energy stores and cholecystokinin, glucagon-like peptide-1, peptide YY(3-36), and ghrelin from the gastrointestinal tract. Of the many gastrointestinal peptides, ghrelin is the only established appetite-stimulating one, whereas cholecystokinin, glucagon-like peptide-1, and peptide YY(3-36) promote satiety. Adipose tissue provides hormonal signals via leptin and insulin to the brain about energy stores and likely from adiponectin and resistin. Binge eating has been related to a dysfunction in the ghrelin signaling system. Moreover, the larger gastric capacity observed in BED may further reduce satiety signals and contribute to overeating.