Parental feeding and childhood genetic risk for obesity: Exploring hypothetical interventions with causal inference methods
Parental feeding and childhood genetic risk for obesity: Exploring hypothetical interventions with causal inference methods
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父母喂养和儿童肥胖遗传风险：用因果推理方法探索假设干预措施
DOI：
10.1101/2021.01.07.21249377
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Herle M
中科院分区：
文献类型：
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作者：
Herle M
背景父母喂养行为是儿童肥胖的常见干预目标，但往往只能带来很小的改变。儿童BMI部分由遗传效应驱动，父母喂养干预在多大程度上可以介导儿童遗传易感性尚不清楚。在这里，我们的目的是研究如何潜在的干预父母喂养的行为可以减轻一些儿童遗传责任和BMI之间的关联，在青春期早期，使用因果推理methodsData从雅芳纵向研究的父母和孩子被用来估计干预差异措施的儿童多基因评分BMI（PGS-BMI）的BMI在12岁。该方法比较了反事实的结果，不同的假设干预父母喂养方式时，儿童10-11岁（n= 4248）。结果以12岁时遗传易感性（PGS-BMI）和BMI之间的调整后总关联（Adj-Ta）与干预差异测量直接效应（IDM-DE）之间的关联形式呈现，后者代表如果我们干预父母喂养，该关联将保持不变在不同的情况下。结果对于遗传易感性处于前五分之一的儿童，将父母喂养转变为遗传风险最低的儿童水平的干预措施，导致12岁时BMI差异为0.81 kg/m2（10-Ta = 3.27，95%CI：3.04，3.49;对IDM-DE = 2.46，95%CI：2.24，2.67）.ConclusionsFindings表明，父母喂养干预有可能缓冲一些儿童肥胖的遗传易感性。此外，我们强调了一种新的方法来分析潜在的干预措施，只使用二手数据分析，结合统计遗传学和社会流行病学的方法。
BackgroundParental-feeding behaviors are common intervention targets for childhood obesity, but often only deliver small changes. Childhood BMI is partly driven by genetic effects, and the extent to which parental-feeding interventions can mediate child genetic liability is not known. Here we aim to examine how potential interventions on parental-feeding behaviors can mitigate some of the association between child genetic liability and BMI in early adolescence, using causal inference methods.MethodsData from the Avon Longitudinal Study of Parents and Children were used to estimate an interventional disparity measure for a child polygenic score for BMI (PGS-BMI) on BMI at 12 years. The approach compares counterfactual outcomes for different hypothetical interventions on parental-feeding styles applied when children are 10–11 years (n= 4248). Results are presented as adjusted total association (Adj-Ta) between genetic liability (PGS-BMI) and BMI at 12 years, versus the interventional disparity measure-direct effect (IDM-DE), which represents the association that would remain, had we intervened on parental-feeding under different scenarios.ResultsFor children in the top quintile of genetic liability, an intervention shifting parental feeding to the levels of children with lowest genetic risk, resulted in a difference of 0.81 kg/m2in BMI at 12 years (Adj-Ta = 3.27, 95% CI: 3.04, 3.49; versus IDM-DE = 2.46, 95% CI: 2.24, 2.67).ConclusionsFindings suggest that parental-feeding interventions have the potential to buffer some of the genetic liability for childhood obesity. Further, we highlight a novel way to analyze potential interventions for health conditions only using secondary data analyses, by combining methodology from statistical genetics and social epidemiology.