Functional Lateralization of Face, Hand, and Trunk Representation in Anatomically Defined Human Somatosensory Areas
Functional Lateralization of Face, Hand, and Trunk Representation in Anatomically Defined Human Somatosensory Areas
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DOI：
10.1093/cercor/bhn039
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发表时间：
2008-12-01
期刊：
影响因子：
3.7
通讯作者：
Zilles, K.
中科院分区：
文献类型：
--
作者：
Eickhoff, S. B.;Grefkes, C.;Zilles, K.
我们使用功能性磁共振成像（fMRI）和cytoarchitectonic概率图来研究人类初级和次级躯体感觉皮层中的各个区域对身体两侧的手、脸或躯干刺激的反应。量化同侧激活概率的贝叶斯建模方法显示，SII皮质的OP 1、OP 4和OP 3区域以及所有SI子区域（区域3b、1和2）内的躯干和面部表征对单侧刺激显示出稳健的双侧反应。这种双边的响应特性是在很好的协议与transcallosal的预测表明，在非人类灵长类动物和其他哺乳动物的这些领域。相比之下，SI手区域显示出不同的模式。虽然同侧区域3b和1被触觉手刺激停用，特别是在左侧，但有强有力的证据表明，同侧处理来自右手的信息在区域2。这些结果表明，不仅手表示的行为的重要性，但也表明，2区可能特别进化形成这些专门的需求，在最近的研究中，假设2区的皮质进化已经发展与增加手动能力的灵长类动物具有对生拇指的皮质基板。
We used functional magnetic resonance imaging (fMRI) and cytoarchitectonic probability maps to investigate the responsiveness of individual areas in the human primary and secondary somatosensory cortices to hand, face, or trunk stimulation of either body-side. A Bayesian modeling approach to quantify the probability of ipsilateral activations revealed that areas OP 1, OP 4, and OP 3 of the SII cortex as well as the trunk and face representations within all SI subareas (areas 3b, 1, and 2) show robust bilateral responses to unilateral stimulation. Such bilateral response properties are in good agreement with the transcallosal projections demonstrated for these areas in nonhuman primates and other mammals. In contrast, the SI hand region showed a different pattern. Whereas ipsilateral areas 3b and 1 were deactivated by tactile hand stimulation, particularly on the left, there was strong evidence for ipsilateral processing of information from the right hand in area 2. These results demonstrate not only the behavioral importance of the hand representation, but also suggest that area 2 may have particularly evolved to form the cortical substrate of these specialized demands, in line with recent studies on cortical evolution hypothesizing that area 2 has developed with increasing manual abilities in anthropoid primates featuring opposable thumbs.