Antennal Lobe Processing Increases Separability of Odor Mixture Representations in the Honeybee
Antennal Lobe Processing Increases Separability of Odor Mixture Representations in the Honeybee
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DOI：
10.1152/jn.00342.2009
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发表时间：
2010-04-01
影响因子：
2.5
通讯作者：
Sandoz, Jean Christophe
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文献类型：
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作者：
Deisig, Nina;Giurfa, Martin;Sandoz, Jean Christophe
Deisig N，Giurfa M，Sandoz JC.额叶处理增加了蜜蜂气味混合物表征的可分离性。J Neurophysiol 103：2185-2194，2010.首次发表于2010年2月24日; doi：10.1152/jn.00342.2009。初级嗅觉中心内的局部网络将气味表征从嗅觉受体神经元重新格式化为二级神经元。通过研究昆虫大脑的主要嗅觉中心触角叶（AL）输入端的混合物表示规则，我们最近发现，蜜蜂的混合物表示遵循严格的基本规则：单独呈现时，一个组件越激活AL，它就越多地表示在混合物中。我们现在通过对一群二级神经元进行成像来研究AL输出端的混合表示，这些二级神经元将AL处理的气味信息传递到更高的大脑中心。我们系统地测量了22个已识别的肾小球对四种单一气味剂及其所有可能的二元、三元和四元混合物的气味诱发活性。通过比较输入和输出响应，我们确定了AL网络如何重新格式化混合物表示，以及这对气味辨别有什么好处。我们发现，在AL内增加抑制导致更多的合成，元素少，混合物表示在输出水平比在输入水平。因此，混合物表示在嗅觉空间中变得更加可分离，从而允许更好地区分自然界中的花卉混合物。
Deisig N, Giurfa M, Sandoz JC. Antennal lobe processing increases separability of odor mixture representations in the honeybee. J Neurophysiol 103: 2185-2194, 2010. First published February 24, 2010; doi: 10.1152/jn.00342.2009. Local networks within the primary olfactory centers reformat odor representations from olfactory receptor neurons to second-order neurons. By studying the rules underlying mixture representation at the input to the antennal lobe (AL), the primary olfactory center of the insect brain, we recently found that mixture representation follows a strict elemental rule in honeybees: the more a component activates the AL when presented alone, the more it is represented in a mixture. We now studied mixture representation at the output of the AL by imaging a population of second-order neurons, which convey AL processed odor information to higher brain centers. We systematically measured odor-evoked activity in 22 identified glomeruli in response to four single odorants and all their possible binary, ternary and quaternary mixtures. By comparing input and output responses, we determined how the AL network reformats mixture representation and what advantage this confers for odor discrimination. We show that increased inhibition within the AL leads to more synthetic, less elemental, mixture representation at the output level than that at the input level. As a result, mixture representations become more separable in the olfactory space, thus allowing better differentiation among floral blends in nature.