Tumor Directed, Scalp Sparing Intensity Modulated Whole Brain Radiotherapy for Brain Metastases
Tumor Directed, Scalp Sparing Intensity Modulated Whole Brain Radiotherapy for Brain Metastases
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DOI：
10.7785/tcrt.2012.500426
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发表时间：
2015-10-01
影响因子：
2.8
通讯作者：
Pettit, Jeffrey
中科院分区：
文献类型：
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作者：
Kao, Johnny;Darakchiev, Boramir;Pettit, Jeffrey
尽管放射治疗技术取得了重大进展，但传统的全脑放射治疗（WBRT）在过去50年中并未发生实质性变化。我们假设调强放射治疗可以选择性地保留未受累的大脑和头皮，以减少急性和晚期毒性。进行MRI/CT模拟图像配准。我们进行了IMRT计划，同时治疗MRI上的脑肿瘤+ 5 mm边缘，15次治疗37.5戈伊，同时限制未受累脑+ 2 mm边缘，15次治疗30戈伊，平均头皮剂量为
Despite significant technical advances in radiation delivery, conventional whole brain radiation therapy (WBRT) has not materially changed in the past 50 years. We hypothesized that IMRT can selectively spare uninvolved brain and scalp with the goal of reducing acute and late toxicity. MRI/CT simulation image registration was performed. We performed IMRT planning to simultaneously treat the brain tumor(s) on MRI + 5 mm margin to 37.5 Gy in 15 fractions while limiting the uninvolved brain + 2 mm margin to 30 Gy in 15 fractions and the mean scalp dose to