Plasma monocyte chemotactic protein-1 levels at 24 hours are a biomarker of primary graft dysfunction after lung transplantation.
Plasma monocyte chemotactic protein-1 levels at 24 hours are a biomarker of primary graft dysfunction after lung transplantation.
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DOI：
10.1016/j.trsl.2012.08.003
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发表时间：
2012-12
期刊：
影响因子：
--
通讯作者：
Ware LB
中科院分区：
文献类型：
--
作者：
Shah RJ;Diamond JM;Lederer DJ;Arcasoy SM;Cantu EM;Demissie EJ;Kawut SM;Kohl B;Lee JC;Sonett J;Christie JD;Ware LB
MCP-1，也称为CCL 2，是在肺上皮细胞中产生的单核细胞吸引趋化因子。我们先前报道了在一项使用多重平台的极端表型的巢式病例对照研究中，肺移植后血浆MCP-1水平升高与原发性移植物功能障碍（PGD）相关。在这项研究中，我们试图评估血浆MCP-1水平作为整个PGD谱的生物标志物之间的关系。我们对肺移植结局组队列中的108例肺移植受者进行了前瞻性队列研究。在移植前、移植后6小时和24小时测量血浆MCP-1水平。主要结局是移植后72小时内发生3级PGD，次要分析在72小时时间点进行。多变量logistic回归用于评估混杂因素。30例受试者（28%）发生PGD。移植后24小时测量的MCP-1中位数在PGD受试者中升高（167.95 vs. 103.5 pg/mL p=0.04）。24小时的MCP-1水平与肺移植后3级PGD的几率增加相关（每100 pg/mL的OR为1.24，95% CI 1.00，1.53），并且在72小时时间点存在3级PGD（每100 pg/mL的OR为1.57，95% CI为1.18，2.08），与多变量分析中的混杂变量无关。术前和移植后6小时测量的MCP-1水平与PGD无显著相关性。在24小时时MCP-1水平的持续升高是移植后3级PGD的生物标志物。单核细胞趋化性可能在PGD的发病机制中起一定作用。
MCP-1, also known as CCL2, is a monocyte-attracting chemokine produced in lung epithelial cells. We previously reported an association of increased levels of plasma MCP-1 with primary graft dysfunction (PGD) after lung transplantation in a nested case control study of extreme phenotypes using a multiplex platform. In this study, we sought to evaluate the relationship between plasma MCP-1 levels as a biomarker across the full spectrum of PGD. We performed a prospective cohort study of 108 lung transplant recipients within the Lung Transplant Outcomes Group cohort. Plasma MCP-1 levels were measured pre-transplantation, 6 and 24 hours after transplantation. The primary outcome was development of grade 3 PGD within 72 hours of transplant, with secondary analyses at the 72- hour timepoint. Multivariable logistic regression was used to evaluate confounding. 30 subjects (28%) developed PGD. Median MCP-1 measured at 24 hours post transplant was elevated in subjects with PGD (167.95 vs. 103.5 pg/mL p=0.04). MCP-1 levels at 24 hours were associated with increased odds of grade 3 PGD after lung transplantation (OR for each 100 pg/mL 1.24, 95% CI 1.00, 1.53), and with grade 3 PGD present at the 72-hour timepoint (OR for each 100 pg/mL 1.57, 95% CI 1.18, 2.08), independent of confounding variables in multivariable analyses. MCP-1 levels measured pre-operatively and 6 hours after transplant were not significantly associated with PGD. Persistent elevations in MCP-1 levels at 24 hours are a biomarker of grade 3 PGD post-transplantation. Monocyte chemotaxis may play a role in the pathogenesis of PGD.
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影响因子：
8.9
作者：
Christie, Jason D.;Bellamy, Scarlett;Kawut, Steven M.
通讯作者：
Kawut, Steven M.
DOI：
10.1164/rccm.200409-1243oc
发表时间：
2005-06-01
影响因子：
24.7
作者：
Christie, JD;Kotloff, RM;Kimmel, SE
通讯作者：
Kimmel, SE
DOI：
10.1164/rccm.200901-0118oc
发表时间：
2009-11-15
影响因子：
24.7
作者：
Christie, Jason D.;Shah, Chirag V.;Ware, Lorraine B.
通讯作者：
Ware, Lorraine B.
DOI：
10.1097/01.asn.0000059339.14780.e4
发表时间：
2003-04-01
影响因子：
13.6
作者：
Furuichi, K;Wada, T;Yokoyama, H
通讯作者：
Yokoyama, H
影响因子：
8.8
作者：
Covarrubias, M.;Ware, L. B.;Christie, J. D.
通讯作者：
Christie, J. D.