The Rcs System in Enterobacteriaceae: Envelope Stress Responses and Virulence Regulation.
The Rcs System in Enterobacteriaceae: Envelope Stress Responses and Virulence Regulation.
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DOI：
10.3389/fmicb.2021.627104
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发表时间：
2021
影响因子：
5.2
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Meng J;Young G;Chen J
细菌细胞被膜是细菌与环境相互作用的前沿保护屏障，其完整性受到各种应激反应系统的调节。Rcs（被膜合成调节因子）系统是一种非正统的双组分调节系统（TCS），存在于肠杆菌科的许多成员中，是被膜应激反应途径之一。Rcs系统可以感知包膜损伤或缺陷，并调节转录组以抵抗应激，这对于病原菌的存活和毒力特别重要。本文综述了Rcs系统在包膜胁迫反应和毒力调控中的作用。我们讨论了环境和内在来源的信封应力，导致激活的Rcs系统，强调的作用，RcsF的信封应力和信号转导的检测。最后介绍了几种常见病原体中Rcs系统控制毒力的不同调控机制。本文综述了Rcs系统在细菌环境适应中的重要作用，为细菌感染的控制、预防和治疗提供了理论依据。
The bacterial cell envelope is a protective barrier at the frontline of bacterial interaction with the environment, and its integrity is regulated by various stress response systems. The Rcs (regulator of capsule synthesis) system, a non-orthodox two-component regulatory system (TCS) found in many members of the Enterobacteriaceae family, is one of the envelope stress response pathways. The Rcs system can sense envelope damage or defects and regulate the transcriptome to counteract stress, which is particularly important for the survival and virulence of pathogenic bacteria. In this review, we summarize the roles of the Rcs system in envelope stress responses (ESRs) and virulence regulation. We discuss the environmental and intrinsic sources of envelope stress that cause activation of the Rcs system with an emphasis on the role of RcsF in detection of envelope stress and signal transduction. Finally, the different regulation mechanisms governing the Rcs system’s control of virulence in several common pathogens are introduced. This review highlights the important role of the Rcs system in the environmental adaptation of bacteria and provides a theoretical basis for the development of new strategies for control, prevention, and treatment of bacterial infections.
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影响因子：
4.5
作者：
Girgis, Hany S.;Liu, Yirchung;Ryu, William S.;Tavazoie, Saeed
通讯作者：
Tavazoie, Saeed
影响因子：
3.2
作者：
GERVAIS, FG;DRAPEAU, GR
通讯作者：
DRAPEAU, GR
影响因子：
3.6
作者：
Domínguez-Bernal, G;Pucciarelli, MG;García-del Portillo, F
通讯作者：
García-del Portillo, F
影响因子：
3.1
作者：
Di Venanzio, Gisela;Stepanenko, Tatiana M.;Garcia Vescovi, Eleonora
通讯作者：
Garcia Vescovi, Eleonora
影响因子：
3.2
作者：
Farris, Carol;Sanowar, Sarah;Miller, Samuel I.
通讯作者：
Miller, Samuel I.