A COMPUTATIONAL MODEL FOR EXPIRATORY FLOW
A COMPUTATIONAL MODEL FOR EXPIRATORY FLOW
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DOI：
10.1152/jappl.1982.52.1.44
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发表时间：
1982-01-01
影响因子：
3.3
通讯作者：
RODARTE, JR
中科院分区：
文献类型：
--
作者：
LAMBERT, RK;WILSON, TA;RODARTE, JR
建立了最大呼气流量的数学模型。耦合方程描述的压力损失在流动和气道的压力-面积行为被集成沿着气道从周边到流量限制的网站。描述流动中压力损失的方程改编自支气管铸型的研究。使用的支气管解剖结构是由Weibel描述的。支气管的机械性能，获得从测量切除的人肺的中央气道和外周气道的这些数据的外推。该模型预测的最大空气流量和最大He流量与获得力学性能的5个肺的最大流量一致。该模型的预测同意与公布的最大流量的密度和粘度的依赖值。在高肺容量和中肺容量时，最大流量主要由波速机制决定。在低肺容量下，最大流量主要由粘性压力损失和气道机械特性的耦合决定。
A mathematical model of maximal expiratory flow was developed. Coupled equations describing the pressure losses in the flow and the pressure-area behavior of the airway were integrated along the airway from the periphery to the flow-limiting site. Equations describing pressure losses in the flow were adapted from studies of bronchial casts. The bronchial anatomy utilized was that described by Weibel. Bronchial mechanical properties were obtained from measurements in excised human lungs for the central airways and by extrapolations of these data for the peripheral airways. The maximal flow for air and He predicted by the model agrees with that of 5 lungs from which mechanical properties were obtained. The model predictions agree with published values of density and viscosity dependence of maximal flow. At high and midlung volumes, maximal flow is determined primarily by the wave-speed mechanism. At low lung volumes, maximal flow is primarily determined by the coupling of viscous pressure losses and airway mechanical properties.