Simplex search in optimization of capsule formulation.
Simplex search in optimization of capsule formulation.
复制标题
胶囊配方优化中的单纯形搜索。
DOI：
10.1002/jps.2600691003
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
R. E. Jones
中科院分区：
文献类型：
--
作者：
E. Shek;M. Ghani;R. E. Jones
以溶出速率和压实速率为优化指标，采用单纯形优化方法对胶囊配方进行优化。研究的配方参数包括药物、崩解剂、润滑剂和填充重量。在胶囊配方优化成功后，将积累的数据拟合到多项式回归模型中，绘制最佳配方周围的响应面图。
The simplex method of optimization was applied to a capsule formulation uing the dissolution rate and compaction rate as the desired responses to be optimized. The formulation parameters investigated included the levels of drug, disintegrant, lubricant, and fill weight. Following the successful optimization of the capsule formulation, the accumulated data were fitted to a polynomial regression model to plot response surface maps around the optimum.