Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems.
Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems.
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DOI：
10.3390/ijms17020172
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发表时间：
2016-02-06
影响因子：
5.6
通讯作者：
Kuroda M
中科院分区：
文献类型：
--
作者：
Ohno S;Drummen GP;Kuroda M
许多类型的细胞释放磷脂膜囊泡，这些囊泡被认为在细胞间通讯、抗原呈递和感染因子的传播中起关键作用。细胞外囊泡（EV）携带各种蛋白质，信使RNA（mRNA）和microRNA（miRNA），就像“瓶中的信息”一样传递给遥远位置的细胞。封装的分子受到保护，免受体液中多种类型的降解酶的影响，使电动汽车成为递送药物的理想选择。本文综述了电动汽车作为天然药物和新型给药系统的潜在作用。
Many types of cells release phospholipid membrane vesicles thought to play key roles in cell-cell communication, antigen presentation, and the spread of infectious agents. Extracellular vesicles (EVs) carry various proteins, messenger RNAs (mRNAs), and microRNAs (miRNAs), like a “message in a bottle” to cells in remote locations. The encapsulated molecules are protected from multiple types of degradative enzymes in body fluids, making EVs ideal for delivering drugs. This review presents an overview of the potential roles of EVs as natural drugs and novel drug-delivery systems.