Epidemiology of Healthcare-Associated Bloodstream Infection Caused by USA300 Strains of Methicillin-Resistant Staphylococcus aureus in 3 Affiliated Hospitals
Epidemiology of Healthcare-Associated Bloodstream Infection Caused by USA300 Strains of Methicillin-Resistant Staphylococcus aureus in 3 Affiliated Hospitals
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DOI：
10.1086/595963
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发表时间：
2009-03-01
影响因子：
4.5
通讯作者：
Burman, William J.
中科院分区：
文献类型：
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作者：
Jenkins, Timothy C.;McCollister, Bruce D.;Burman, William J.
OBJECTIVE.描述在医疗机构中由USA300株耐甲氧西林金黄色葡萄球菌（MRSA）引起的血流感染的流行病学，MRSA通常与社区获得性感染病例相关。回顾性队列研究。科罗拉多州丹佛市的三家学术附属医院。回顾S.在2003年至2007年期间，金黄色葡萄球菌血流感染。用聚合酶链反应鉴定MRSA USA300分离株。研究期间共发生330例MRSA血流感染，其中286例（87%）与医疗保健相关。耐甲氧西林的沙门氏菌的耐药率为100%。在研究期间，回收的金黄色葡萄球菌分离株没有变化，并且在3家医院之间相似。然而，由USA300菌株引起的医疗保健相关MRSA血流感染病例的百分比在3家医院之间差异很大：62%、19%和36%（P
OBJECTIVE. To describe the epidemiology of bloodstream infection caused by USA300 strains of methicillin-resistant Staphylococcus aureus (MRSA), which are traditionally associated with cases of community-acquired infection, in the healthcare setting.DESIGN. Retrospective cohort study.SETTING. Three academically affiliated hospitals in Denver, Colorado.METHODS. Review of cases of S. aureus bloodstream infection during the period from 2003 through 2007. Polymerase chain reaction was used to identify MRSA USA300 isolates.RESULTS. A total of 330 cases of MRSA bloodstream infection occurred during the study period, of which 286 (87%) were healthcare-associated. The rates of methicillin resistance among the S. aureus isolates recovered did not vary during the study period and were similar among the 3 hospitals. However, the percentages of cases of healthcare-associated MRSA bloodstream infection due to USA300 strains varied substantially among the 3 hospitals: 62%, 19%, and 36% (P