Effect of vitamin D replacement on musculoskeletal parameters in school children: A randomized controlled trial
Effect of vitamin D replacement on musculoskeletal parameters in school children: A randomized controlled trial
复制标题
DOI：
10.1210/jc.2005-1436
复制
发表时间：
2006-02-01
影响因子：
5.8
通讯作者：
Vieth, R
中科院分区：
文献类型：
--
作者：
El-Hajj Fuleihan, G;Nabulsi, M;Vieth, R
背景：尽管全球儿童和青少年维生素D缺乏症的患病率很高，但维生素D缺乏对骨骼健康的影响尚不清楚。方法：在一项为期1年的双盲、安慰剂对照研究中，179名年龄在10-17岁的女孩被随机分配接受每周口服维生素D剂量1400 IU（相当于200 IU/ D）或14000 IU（相当于2000 IU/ D）。在基线和1年时测量腰椎、髋部、前臂、全身和身体组成的骨矿物质密度（BMD）和骨矿物质含量（BMC）。在研究期间测量血清钙、磷、碱性磷酸酶和维生素D代谢物。结果：在整个组中，高剂量组的BMC升高（P < 0.02）。在月经前女孩中，两个治疗组的瘦质量都显著增加，并且在几个骨骼部位的骨密度和/或BMC都有一致的增加趋势，低剂量组的腰椎骨密度和两个治疗组的粗隆BMC都有显著增加。月经初潮后女孩的瘦质量、骨密度或BMC没有显著变化。结论：维生素D替代对女孩的肌肉骨骼参数有积极影响，特别是在月经前期。
Background: Despite the high prevalence of hypovitaminosis D in children and adolescents worldwide, the impact of vitamin D deficiency on skeletal health is unclear.Methods: One hundred seventy-nine girls, ages 10-17 yr, were randomly assigned to receive weekly oral vitamin D doses of 1,400 IU (equivalent to 200 IU/d) or 14,000 IU (equivalent to 2,000 IU/d) in a double-blind, placebo-controlled, 1-yr protocol. Areal bone mineral density (BMD) and bone mineral content (BMC) at the lumbar spine, hip, forearm, total body, and body composition were measured at baseline and 1 yr. Serum calcium, phosphorus, alkaline phosphatase, and vitamin D metabolites were measured during the study.Results: In the overall group of girls, lean mass increased significantly BMC increased in the high-dose group (P < 0.02). In premenarcheal girls, lean mass increased significantly in both treatment groups, and there were consistent trends for increments in BMD and/or BMC at several skeletal sites, reaching significance at lumbar spine BMD in the low-dose group and at the trochanter BMC in both treatment groups. There was no significant change in lean mass, BMD, or BMC in postmenarcheal girls.Conclusions: Vitamin D replacement had a positive impact on musculoskeletal parameters in girls, especially during the premenarcheal period.